1910-11.] Bone Growth in absence of Functioning Testicles. 103 
8. Prostate. 
The glandular tissue was extremely small in amount. 
9. Penis. 
The structure was normal. 
10. Testicle. 
The fibrous tissue was excessive in amount. The straight tubules were 
normal. The seminiferous tubules were absent, but were represented by 
groups of epithelial cells lying in the meshes of the fibrous tissue, and here 
and there by small ducts lined with a simple stratified or columnar 
epithelium. No healthy tubules were discovered. No spermatozoa were 
seen. 
Summary and Interpretation of Microscopic Observations. 
The testicle was functionless. The pituitary and thyroid glands 
showed departures from the normal, which were interpreted as indicative of 
an increased activity. This was deduced from the increase in the number 
of the granular cells in the anterior lobe of the pituitary, and the increase 
in the amount of colloid in the thyroid. The suprarenal was normal. 
The condition of the prostate was regarded as a direct result of the failure 
of the testicles. 
B. Dissection. 
Beyond the small size of the testicles and the small size of the 
suprarenals, no structural abnormalities of importance were noted, except 
that there was a very imperfect development of the anterior part of the 
antrum of Highmore. This caused a deep concavity on the facial surface 
of the superior maxilla ( vide infra — Description of Skeleton). Another 
interesting abnormality, but probably in no way connected with the general 
condition, was that the left nasal duct opened into the middle meatus of the 
nose (7). 
C. Description of the Skeleton. 
1. Skull. 
The skull of subject A 9, when viewed from the front, is remarkable for 
the depth of the concavity of the facial surface of the superior maxilla, and 
for the way in which the roots of the teeth are exposed on the outer aspect 
of the alveolar process. These two peculiarities are associated with a 
