1910-11.] Bone Growth in absence of Functioning Testicles. 137 
giantism, but the writer hopes to be able to publish shortly, in a paper 
which is in course of preparation, the evidence upon which this suggestion 
is based (9). All that is desirable at the present time is to point out that 
the known effects of pregnancy on body growth are not necessarily opposed 
to the hypothesis that the stimulant effect of castration upon endochondral 
ossification is direct, and is due to the increase in the supply of nutrition 
delivered to the cartilage cells when the demands of the sexual glands are 
withdrawn. It is desirable to repeat that this hypothesis in no way 
excludes the possibility of some of the changes in body form being due to 
the absence of an internal secretion of the testicle, or to the absence of 
certain nervous stimulations normally consequent upon its activity. All 
that is advanced is that the increase of endochondral bone growth is a 
direct result of the increased nutrition of the somatic cells. It certainly 
seems highly improbable that the restraint in the growth of the penis and 
scrotum, the arrest of the development of the anterior part of the antrum 
of Highmore, and the possible arrest in the growth of the brain, are to be 
attributed to the same cause. These would seem more probably to be due 
to the absence of some internal secretion, or to the absence of some nervous 
stimulation. 
Table XLI. — Height and Growth — Rate of Industrial School Children (32). 
Height. 
No. of 
Age. 
Sex. 
Increase, 
Observations. 
Feet. 
Inches. 
Inches. 
11 
2 i 
( 
M. 
F. 
2* 
7**95 
15 
f 
l 
M. 
F. 
2 
2 
10- 50 
11- 50 
3-4 
28 
■*\ 
r 
M. 
F. 
3 
3 
0- 27 
1- 07 
1-8 
1-5 
80 
H 
f 
M. 
F. 
3 
3 
2-63 
3.22 
2-4 
2-2 
92 
d 
r 
M. 
3 
5-14 
2-5 
L 
F. 
3 
5-15 
1-9 
109 
f 
M. 
F. 
3 
3 
7-54 
6-38 
2-4 
1-2 
135 
8 1 
r 
M. 
F. 
3 
3 
8-61 
8-68 
IT 
2-3 
It is clear that for this division of the effects of castration into two 
categories to be proved correct, it is necessary for those which are 
hypothesised as being the result of simple nutritional excess to be clearly 
demonstrated as occurring, to some extent at least, in normal, healthy, 
