1910-11.] 
A Study of Artificial Pyrexia. 
333 
XIX.— A Study of Artificial Pyrexia produced by Tetra-hydro-^- 
N aphthylamine Hydrochloride. By Adam Black. (From the 
Physiological Department, Glasgow University.) Communicated by 
Professor D. Noel Paton. 
(MS. received February 6, 1911. Bead January 23, 1911.) 
The object of the present investigation is to throw further light upon the 
differences between the disturbances in the chemical processes in the body 
in fever caused, on the one hand, by the mere rise of body temperature, and 
on the other by the action of the micro-organismal poisons on the tissues of 
the body. 
The influence of such micro-organismal poisons has been already studied 
by several investigators — among others, by Noel Paton, Dunlop, and 
Macadam in the case of diphtheria ( Journ . of Phys., vol. xxiv. p. 331, 1899 ; 
see also chapter “ Fever and Infection,” by Kraus, Yon Noorden’s Meta- 
bolism and Practical Medicine , vol. ii. p. 90) ; but so far few detailed studies 
of the metabolism in high temperature due to non-infectious processes have 
been recorded. 
It has been maintained that, while bacteria and their toxins cause an 
increased disintegration of proteins, simple pyrexia is entirely caused by 
an increased combustion of glycogen. 
The peculiar action of tetra-hydro-/3-naphthylamine hydrochloride in 
causing a rise of temperature seems to afford a means of differentiating the 
effects of mere high temperature from the effects of ordinary infective fevers. 
In 1889 Stern (1 and 2) showed that after the injection of a small dose of 
this substance there is a distinct rise of temperature. He investigated the 
effects of the drug with considerable care, but came to no definite con- 
clusions as to its mode of action. Fawcett and Hale- White (3) also made 
observations on the action of the drug, and concluded that the rise of 
temperature is not due to diminution in the loss of heat, and that it is not 
due to muscular movement. They also attempted to study the effect of the 
drug when the spinal cord is cut, and when the rabbit is under the influence 
of curare ; but they came to the conclusion that the influence of the fixing 
down of the animal renders all conclusions from such experiments valueless. 
They also record some experiments on the combined effect of fixing down 
the rabbit and performing artificial respiration with the administration of 
ether alone and combined with the drug. The result seems to have been 
