337 
1910-11.] A Study of Artificial Pyrexia. 
A further set of experiments were carried out in which the drug 
was first injected and the temperature of the animal allowed to rise 
definitely before the administration of the ether was commenced. In 
these experiments a fall of temperature began at once, and at about the 
rate of T7° C. in the first hour. When the ether was stopped there was 
not the same tendency as in the previous set of experiments for the 
temperature to rise above the normal, the recovery, in fact, being rather 
slow (see Chart VI.). 
The administration of an anaesthetic (ether) prevents or checks the 
rise of temperature produced by the drug. This action may be due to the 
anaesthetic acting in one of three ways : — 
(1) By poisoning a hypothetical heat-producing centre upon which the 
drug may act. 
VOL. XXXI. 
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