339 
1910-11.] A Study of Artificial Pyrexia. 
always cold during the rise of temperature under the influence of the drug, 
and continued cool while the temperature was falling, suggests that vaso- 
contraction with decreased loss of heat is an important factor in bringing 
about the rise of temperature. 
As regards the first hypothesis, that the anaesthetic paralyses a thermo- 
genic centre on which the drug acts, no definite experiments are at present 
put forward. But the evidence given above seems to indicate that this 
antagonistic action is not of primary importance. 
B. Influence of the Drug on Nitrogenous Metabolism. 
Two experiments were done on dogs. 
Exp. 1. The results of this experiment are given in detail (see Tempera- 
ture Chart IX.). 
Exp. 2. The results of this experiment confirm 1 in all respects, and 
are not given (see Temperature Chart X.). 
Experiment 1. — Setter , Female. 
Weight, Nov. 13 : 18-200 kilos. 
22: 16*700 
Diet : 150 grams oatmeal. 
25 „ plasmon. 
500 c.c. milk. 
Given daily in one meal at 10 a.m. 
Dates given opposite urinary analysis are those of the days of collecting 
the urine passed in the preceding twenty-four hours : the urine was 
collected at 10 a.m. 
At 12 noon on the 17th November 0’2 gram of drug was given 
hypodermically. 
