341 
1910-11.] A Study of Artificial Pyrexia. 
From the table it will he noted that as the result of the injection there 
is a very slight rise in the output of total nitrogen. This agrees with the 
result of a similar experiment carried out by Stern (2). There is a slight 
fall in the percentage of urea nitrogen and a slight rise in the total purins 
and in the creatinine, although the dog’s food was practically purin and 
creatine free. Leathes (9) found that the output of both of these was 
increased during fever. Van Hoogenhuyze and Verploegh (8) also found 
an increased output of creatinine in the same condition. The retention of 
chlorides so characteristic of all pyrexias is quite marked. 
Conclusions. 
The investigation thus goes to show (1) that tetra-hydro-8-naphthyl- 
amine hydrochloride is a drug which induces a high temperature by acting 
upon the nervous system, and that its action may be antagonised by ether, 
and that in all probability the rise of temperature under the drug is due to 
decreased heat-elimination. 
(2) That the change produced in the nitrogenous metabolism by so 
marked a pyrexia as that induced by the drug is very small when com- 
pared with the change produced by such agents as diphtheria toxin. This 
tends to show that it is the action of toxins on the tissues rather than the 
pyrexia which modifies the protein metabolism. 
My thanks are due to Dr Cathcart for suggesting to me the subject 
of research, and to him and to Professor Noel Paton for assistance in its 
prosecution. 
(Towards the expenses of the investigation a grant was made by 
Mr Francis Mason.) 
BIBLIOGRAPHY. 
1. Stern, Virchow's Archiv, cxv. p. 13, 1889. 
2. „ „ „ cxxi. p. 376, 1890. 
3. Fawcett and Hale White, Journal of Physiology , xxi. p. 435, 1897. 
4. Hale-White and Pembrey, “Proc. of the Phys. Soc.,” Journ. of Phys., 1903. 
5. Ott, Journ. of Exp. Medicine , vol. ix. No. 6, 1907 ; Contributions to 
Physiology , part xvii., 1907 ; ibid., part xviii., 1909. 
6. Harnack, Arch. f. exp. Pathol ., xlix. p. 157, 1903. 
7. Marshall (communication to Dr Cathcart). 
8. Van Hoogenhuyze and Verploegh, Ztsch. f. physiol. Chemie, Bd. lvii. 
p. 161, 1908. 
9. Leathes, Journal of Physiology , vol. xxxv. p. 205, 1907. 
(Issued separately April 12, 1911.) 
