1889-90.] Mr Dott and Dr Stockman on Morphine. 
333 
determine both points we had to institute special experiments. 
The results of these are given in the following Tables. 
Three decigrms. of morphine hydrate given subcutaneously was 
usually a fatal dose for medium-sized rabbits. This is equal to 
about 037 grm. of morphine hydrochlorate, sulphate, or tartrate, 
to 0*4 grm. acetate, and 0'43 grm. meconate. Certain rabbits were 
killed with less, and others required more. The minimum lethal 
dose of any substance can hardly be fixed with complete accuracy, 
as the rate of absorption and excretion, the condition of health of 
the animal, along with other less evident factors, all influence the 
result and make it variable. In addition to our own results, 
Lenhartz has found the minimum lethal dose of morphine per 
kilo, in dogs to vary from 027 to 059 grm., while recovery took 
Table of Experiments made to fix the Minimum Lethal Dose of 
Morphine Hydrate in Rabbits. 
No. y 
Weight of Rabbit 
in Grms. 
Dose of Morphine 
Hydrate in Grms. 
Dose per Kilo, of 
Body Weight. 
Deeply Narco- 
tised in 
Pupils after Con- 
tracting began to 
Dilate in 
Increased Reflex 
apparent in 
First Marked 
Tetanic Spasm in 
Result. 
1 
1548 
0-28 
0-180 
min. 
min. 
hr. min. 
0 55 
hr. Min. 
1 5 
Death in 1 hour 19 minutes. 
2 
1530 
“ 0-25 
0-163 
8 
16 
0 36 
1 36 
There were very frequent 
tetanic attacks and nearly 
continuous slight trem- 
bling. 
Recovery nearly complete in 
3 
Same 
0-28 
0-183 
10 
20 
0 35 
None ; 
6 hours. The convulsions 
were never severe. 
Recovery in 5 hours. 
4 
5 
Same 
Same 
0-3 
0-35 
0-196 
0-228 
0 30 
simply 
tremors 
2 0 
Recovery in 6 hours after 
very severe tetanus. 
Death in 2 hours 18 minutes. 
6 
1530 
0-3 
0-196 
3 
35 
0 35 
3 5 
Death in 3 hours 45 minutes. 
7 
1445 
0-3 
0-207 
6 
15 
0 9 
2 15 
The convulsions were very 
severe, and consisted of 
almost continuous clonic 
spasms, with frequent tonic 
spasms. Died quietly in 
state of exhaustion. 
Death in 3 hours 35 minutes. 
8 
1757 
0-3 
0-170 
6 
38 
0 38 
1 8 
Symptoms as in Expt. 6. 
Death in 1 hour 43 minutes. 
9 
1614 
0-3 
0-185 
1 20 
None. Only 
Symptoms as in Expt. 6. 
Recovery in about 6 hours. 
10 
11 
Same 
Same 
0-35 
0-4 
0-216 
0-247 
tremors 
and slight 
startings. 
Recovery in about 5 hours. 
Had marked tetanus. 
Death in 3 hours 25 minutes. 
Symptoms as in Expt. 6. 
