334 Proceedings of Royal Society of Edinburgh . [sess. 
place after 0*13 to 0*46 grm. per kilo. Distinct narcosis occurred 
in medium-sized rabbits after 5 milligrms., smaller amounts than 
this having a scarcely perceptible effect. The smallest dose with 
which an increase of reflexes was obtained was 0*15 grm. (see 
Tables). 
Table showing the Effects of Small and Medium Doses of 
Morphine Hydrate on Rabbits. 
No. 
j Weight of Rabbit 
in Grms. 
Dose in 
Grms. 
Dose per Kilo. Body 
Weight. 
Effects. 
1 
907 
0*0025 
0*0027 
Scarcely perceptible drowsiness. Not much 
change in demeanour. 
2 
1692 
0*005 
0*003 
Slight narcosis observed 18 minutes after ad- 
ministration, and lasted 3 hours. Respira- 
tion fell about two-thirds. Ears hypersemic 
and blood-vessels dilated. 
3 
0*01 
Light narcosis in 14 minutes, and lasted 4 
hours. Respiration fell from 30 to 4 per 10 
seconds. Pupil became somewhat smaller. 
4 
1650 
0*02 
0*012 
Light narcosis observed in about 10 minutes, 
and lasted 6 hours. Respiration fell from 
30 to 6 and 4 per 10 seconds. Pupil some- 
what smaller. 
5 
1304 
0*05 
0*038 
Narcosis marked in 4 minutes, and lasted all 
day. It was deep, and animal could hardly 
be roused. Pupils were extremely small all 
the time. Respiration fell from 22 to 4 per 
10 seconds. 
6 
1420 
0*1 
0*07 
Deep narcosis set in after 2 minutes and lasted 
all day. Pupils extremely small all the time. 
Respiration fell from 25 to 3 per 10 seconds. 
When severely pinched only made a slight 
movement. There was no increase reflexes. 
7 
907 
0*15 
0*16 
Deep narcosis 1 hour 1 8 minutes after admini- 
stration. There was slight increase in re- 
flexes, which passed off very soon, the narcosis 
remaining deep. The pupil was at first very 
much contracted, but 17 minutes after ad- 
ministration became rather larger and re- 
mained so. It never dilated more than to a 
small medium size. 
8 
1304 
0*2 
0*15 
There was rapidly deep narcosis. 38 minutes 
after administration pupil had dilated to large 
medium size and remained so. In 2 hours 
28 minutes there was slight increase reflexes 
and animal was restless and gnashing its 
teeth. Respiration fell from 15 to 5 per 10 
seconds. Effects lasted all day. 
