341 
1889-90.] Mr Dott and Dr Stockman on Morphine. 
12.0. — Narcosis deeper; reflex excitability is diminishing. 
H., 26; R, 12. 
1.30. — Lying on belly with head on table; is easily aroused but 
relapses at once into somnolence. Sometimes gives a faint twitch. 
H., 30 ; R, 8. 
3.30. — Has gradually recovered, and, although still very sleepy, is 
now sitting up. 
5. 30. — Almost completely recovered, but still sleepy and lethargic. 
H., 33 ; R, 13. 
Action of Hydrochlorate of Etliylmorphine on Rabbits. 
No. 
Weight of Rabbit 
in Gratis. 
Dose 
in 
Grms. 
Dose per Kilo. Body 
Weight. 
Remarks. 
1 
1247 
o-oi 
0-008 
Was slightly drowsy for 3 hours. 
2 
963 
0-02 
0-021 
Very distinctly narcotised for about 4 hours. 
Respiration fell from 29 per 10 seconds to 4. 
Ht. from 34 to 26. Was always easily roused. 
No increase reflexes. 
3 
963 
0-02 
0-021 
Same as in Experiment 2. 
4 
1247 
0-05 
0-04 
Lay as if deeply asleep for 2 hours, and then 
gradually recovered. Respiration fell from 19 
to 11. Ht. and pupil remained unaltered. 
Could always be easily roused. 
5 
1502 
0*08 
0-053 
Experiment 9 in text. 
6 
1190 
0*08 
0-066 
Almost same as 5. 
7 
963 
o-oi 
0103 
Was at first narcotised, but in 6 minutes had 
clonic spasms, and in 9 minutes violent tetanus, 
during which it died. Post mortem was negative. 
The action of ethylmorphine is therefore, so far as our experi- 
ments permit us to judge, exactly similar to that of codeine, and 
stands in the same relation to morphine. 
A mylmorphine. 
This compound was formed in the same manner as the methyl 
and ethyl derivatives, by allowing morphinate of soda and amyl 
chloride to react together in alcoholic solution, with subsequent 
evaporation and extraction with chloroform. On converting the 
base into muriate the salt readily crystallised. 
