342 Proceedings of Boyal Society of Edinburgh. [sess. 
Of the chloroplatinate -3115 grm. gave *055 grm. Pt = 17*68 per 
cent. 
2[Ci 7 Hi8(C 5 Hii)N0 3 ]PtH 2 Cl 6 = 1 7*48 per cent. Pt. 
Physiological Action of Amylmorphine. 
The hydrochlorate of amylmorphine was used, but as the results 
showed its action to be very similar to, if not identical with, that 
of methyl- or ethylmorphine, it is unnecessary to go into further 
details. 
A cetylmorphine. 
The acetyl derivatives of morphine "were first investigated by 
Wright. In our first experiments we prepared acetylmorphine by 
the action of boiling glacial acetic acid on morphine for several 
hours, but we found on analysis of the substance prepared in that 
way that it evidently contained morphine. Better results were 
obtained by heating together at 100° C. equivalent proportions of 
anhydrous morphine and acetic anhydride. After reacting for an 
hour, water was added, and ammonia in slight excess. The mixture 
was then shaken up with ether, in order to remove the acetyl- 
morphine, and the ethereal solution agitated with hydrochloric acid, 
which caused the acetylmorphine to separate as hydrochloride. This 
salt is rather sparingly soluble in water. The chloroplatinate dried 
at 100° lost no w r eight further by drying at 130°. 
•124 grm. gave by ignition *023 grm. Pt= 18*54 per cent. 
2[Ci 7 His(C 2 H30)N0 3 .HC 1 ]PtC 1 4 = 18*48 per cent. Pt. 
The salt, as prepared by the action of glacial acid on morphine, 
gave a chloroplatinate, yielding 18*20 per cent. Pt. 
Physiological Action of Acetylmorphine. 
The only previous experiments with this alkaloid are those of 
F. M. Pierce, who obtained it from C. R. A. Wright. He made 
three observations on dogs and two on rabbits. These were 
sufficient to demonstrate that the action has a general resemblance 
to that of codeine, but they do not show what relationship qualita- 
tively and quantitatively exists between acetylmorphine and the 
other members of the morphine group. 
Our own observations were made on frogs, rabbits, and dogs. As 
