343 
1889 - 90 .] Mr Dott and Dr Stockman on Morphine. 
the hydrochlorate is not a very soluble salt, we used a solution of 
acetylmorphine in water and acetic acid. 
Frogs. — Doses of 5 milligrms. caused restlessness, but no character- 
istic symptoms. When 0*01 grm. is exhibited the frog shows perfectly 
the two stages, although neither the narcotic nor the tetanic condi- 
tion is very pronounced. With 0*015-0*025 grm. there is marked 
lethargy and depression of reflexes, followed in a very short time by 
violent tetanic spasms. The larger the dose the more rapidly does 
tetanus ensue. 
If a solution (2-3 centigrms.) be injected directly into the aorta 
tetanus ensues at once without any preliminary depression of reflexes. 
Acetylmorphine paralyses or depresses motor nerves to very much 
the same extent as codeine does. 
The heart is markedly slowed. After 0*01 grm. the rate fell from 
56 to 44 per minute. 
The following experiments show its general action : — 
Expt. 10. — Frog, 26 grms. K., 20 in 10 seconds. 
2.40. — 0*01 acetylmorphine subcutaneously. 
2.48. — Mery dull and lethargic. Pupils smaller. R., 17. 
3.0 — Lies on back if placed there. Jumps very clumsily. 
Pupils small. R., 8. Reflexes diminished. 
3.42. — In same condition. 
4.22. — Pupil now very large; slight increase in reflexes. Is 
active and lively. 
5.10. — About same. Narcosis has now passed off. 
Next day, active and lively. Slight increase of reflexes. 
Expt. 11. — Frog, 28 grms. R., 18 in 10 seconds. 
10.59. — 0*025 under skin of back. 
11.2. — Much more sluggish ; pupil smaller. R., 14. 
11.10. — R. ceased. Lies on back; pupil very small; responds 
only to severe pinching. 
11.16. — Is still much narcotised, but each irritation brings on a 
tetanus. Pupil remains small during the spasm. 
11.20 — Lying in strychnine position. Tetanus occurs spontane- 
ously and on irritation. 
11.35. — Is very exhausted after each spasm, so that irritation 
does not bring on another until after an interval. Corneal reflex 
gone. 
