344 Proceedings of Royal Society of Edinburgh. [sess. 
12.10. — Yery much exhausted, and on irritation gives simply a 
jerk. 
12.30. — Lying as if dead. Only sign of life is heating of heart, 
10 in 30 seconds. 
Rabbits. — In rabbits the narcotic action is developed after the 
very small dose of one milligrm. The stupor is by no means pro- 
found, but the animal remains drowsy for some hours ; the pupils 
are small, and the respirations are diminished in frequency. When 
the dose is gradually increased there occurs marked narcotism, with 
great weakness in the limbs, and remarkable slowing of the respiration. 
The respiration may be so much slowed that the blood is not 
properly aerated and dyspnoea results. When the dose is increased 
to 0T5-0’25 grm. the narcotic stage is much shortened, the 
increase of reflex excitability comes on more quickly, and proceeds 
to clonic or tonic spasms and death. The heart becomes very 
feeble towards the end. 
Just as with other members of the morphine group, the narcotised 
condition of the brain does not wholly pass off during the tetanic 
stage, although it seems to be a good deal lessened, probably by the 
constant irritation and state of disquietude in which the animal is 
kept by the spasms. 
Dogs. — In a spaniel weighing 13 kilogrms., 1 milligrm. subcutane- 
ously caused slight drowsiness ; larger doses (1-4 centigrms.), while 
having a more marked narcotic effect, had a distinct tendency to 
cause nausea and looseness of the bowels. 
Expt. 12. — Rabbit, 1474 grms. Ht., 27; R., 13 in 10 seconds. 
1.22. — 0T acetylmorphine subcutaneously. 
1.24. — Head on table. H., 22, irregular and intermittent; R., 2. 
1.30. — H., 24, regular; R., 2. Holds head in air as if suffering 
from dyspnoea. Pupil slightly smaller. 
1.37. — H., 27; R., 2 in 15 seconds; head still held up. Lying 
on belly, with legs spread out. 
1.45* — Reflex excitability is increased. 
1.55. — H., 27 ; R., 3. Noise or touch causes slight start. 
2.40. — H., 24 ; R., 5, Reflexes very little increased. Legs very 
weak ; cannot stand. 
4.10. — H., 26; R., 6. Is still a good deal narcotised. Reflexes 
not increased now. 
