1889 - 90 .] Mr Dott and Dr Stockman on Morphine. 
345 
7.30. — H., 26 ; R., 4. Is still a good deal narcotised. Next day, 
well. 
Expt. 13. — Rabbit, 935 grms. H., 29; R., 22 in 10 seconds. 
9.56. — 0T5 acetylmorphine in 10 seconds. 
9.58. — H., 25 ; R. scarcely perceptible. Lying on belly 7 ', with 
head on table. Pupil extremely small. 
10.2. — H., 28; seems scarcely to breathe. Evidently suffering 
from dyspnoea, as it holds its head backwards and upwards. No 
increase reflexes. Pupil still very small. 
10.10. — H., 29; R., 3. Slight increase reflex excitability. 
10.15. — Had slight tetanic jerk. 
10.25. — Has clonic spasms continuously, trembling and jerking. 
H., 25 ; R, 5. Pupils medium. 
10.32.— Clonic spasms more violent. 
11.0. — H., 27 ; R., 6. Spasms not quite so frequent. 
11.45. — Tendency to spasm is rapidly passing off. Lying on 
belly with chin on table ; legs are sprawled out, and so weak that 
rabbit cannot move itself. H., 28; R., 8. 
12.30. — Has lain quietly. H., 29; R, 3. Pupil medium. 
Stimulation still causes slight spasm. 
2.5. — H., 29; R., 6. Lying on side; still gives occasionally a 
slight jerk. Resp. is extremely faint and hardly perceptible. 
2.20. — Died quietly from gradual failure of respiration. 
Post-mortem. — Appearances of asphyxia. 
In acetylmorphine the same hydrogen atom of morphine has been 
replaced as in methyl- or ethylmorphine, but by an acid radical 
(acetyl) instead of an alkyl radical. Its action is much nearer to 
that of codeine than to that of morphine. 
Compared with morphine, its power of causing tetanus is much 
increased, while its narcotic effects, although visible after smaller 
doses, are not nearly so deep. As soon as we increased the dose 
for the purpose of deepening the narcosis, the increase of reflexes 
was developed and disturbed the narcotic effect. The depressant 
action which it exerts on respiration is much greater than that of 
morphine. 
Compared with codeine, an equal narcotic effect is induced in 
rabbits by about one-tenth of the dose, while about a three times 
larger dose is necessary to cause tetanus. Qualitatively, therefore, 
