1889-90.] Mr Dott and Dr Stockman on Morphine. 347 
was evaporated, taken up with water, and slight excess of sodium 
carbonate added. The mixture was then shaken up with chloro- 
form, which on evaporating left a crystalline residue. This was 
dissolved in hot alcohol, the solution left to crystallise, and the 
crystals separated and pressed. From these a chloroplatinate was 
prepared, and a portion of it dried in water-bath. 
*255 grm. gave ‘043 Pt. = 16*86 per cent. 
Portion dried in air-bath at 130° C. 
•2985 grm. gave *0505 Pt= 16*91 per cent. 
2[Ci 7 Hi r (C 2 H 3 0) 2 N0 3 .HCl]PtCl 4 = 17*13 per cent. 
Physiological Action of Diacetylmorphine. 
Pierce also made a few experiments on dogs with this alkaloid, 
and obtained much the same results as with acetylmorphine. 
Our experiments were made on frogs, rabbits, and dogs with a 
solution of diacetylmorphine in acetic acid and water. 
We found its action to be exactly similar to that of acetylmor- 
phine, and hence a detailed account is superfluous. It seems to us 
to be slightly more active, both as a narcotising and tetanising agent, 
but otherwise there is no difference. The lethal dose is about the 
same, and the same very remarkable slowing of the respiration was 
observable. 
For purposes of comparison we give notes of some of the experi- 
ments. 
Expt. 14. — Babbit, 1530 grms. H., 34; B. 19 in 10 seconds. 
12.48. — 0‘01 diacetylmorphine subcutaneously. 
12.50. — Drowsy. 
12.52. — H., 27; E., 3. Pupils much smaller; chin resting on 
table, exactly as if sound asleep. 
12.58. — H., 29 ; E., 1. Blood in ear vessels looks very venous. 
1.30. — H., 30; E., 2. Very narcotised, no increase reflexes. 
2.0. — H., 33; B., 5. 
2.30. — H., 29; B., 2, Lying as if very sound asleep. Easily 
roused, but falls asleep again almost at once. 
3.30. — H., 30 ; B., 3. About same. 
4.30. — H., 29 ; B., 6. Still rather drowsy; can move about, but 
legs are very shaky and weak. 
Expt. 15. — Eabbit, 840 grms. H., 28; B., 15 in 10 seconds. 
