348 
Proceedings of Royal Society of Edinburgh. 
10.53. — 042 grm. diacetylmorphine subcutaneously. 
10.55. — H., 29 ; R., 2. Pupils smaller; lying on belly. 
11.0. — H., 30; R., 3. Increase of reflexes marked; pupil large. 
11.6. — Violent tetanic convulsion, followed shortly by two more. 
11.20. — Lying on belly; frequently starts violently, and some- 
times has tetanus. H., 28 ; R., 3. 
12.30. — Clonic spasms have been nearly continuous ; head, neck, 
and legs are jerked almost without ceasing, and the teeth are gnashed. 
Touch causes a start. H., 28 ; R., 3. 
2.30. — Has been same, and has had several violent tetanic attacks. 
2.50. — Lying on side, having frequent tetanic attacks, very nearly 
dying in each. Pupil large. H., 12; R., 4. 
3.20. — Died during a convulsion. 
Post-mortem examination was negative, except the ordinary 
appearances of death by asphyxia. 
Action of Diacetylmorphine on Rabbits. 
No. 
Weight of Rahhit 
in Grms. 
Dose in 
Gnns. 
Dose per Kilo. Body 
Weight. 
Effects. 
1 
1474 
o-ooi 
0-0006 
Was drowsy for about 2 hours ; respiration fell 
from 19 to 9 per 10 seconds. 
2 
750 
o-ooi 
0-0013 
Was drowsy for 3 hours ; respiration fell from 
17 to 8. 
3 
1530 
0-005 
0-0032 
Was drowsy in 2 minutes ; in 4 minutes lay 
down with chin on table ; pupils verj T small ; 
in 14 minutes respiration was 3 in 10 seconds ; 
weak on legs and cannot stand. Remained 
considerably narcotised for 4 hours. 
4 
1530 
0-01 
0-065 
Experiment 14 in text. 
5 
935 
0-02 
0-021 
In 6 minutes respiration fell from 18 to 2 per 10 
seconds. Lay as if deeply asleep ; pupils 
small ; legs very weak. Remained so for 6 
hours. 
6 
1530 
0-04 
0-026 
Became deeply narcotised in a few minutes. 
Temperature, pulse-rate, and respiration fell ; 
great weakness in legs. Remained so all day. 
7 
954 
0-05 
0-052 
Was deeply narcotised all day. 
8 
840 
0-12 
0-14 
Experiment 15 in text. 
9 
1530 
0-15 
0*098 
Much the same as in Experiment 8, but re- 
covered. 
In a dog weighing 7400 grms. the administration of 5 milli- 
grammes caused drowsiness for three hours. There was consider- 
