350 Proceedings of Royal Society of Edinburgh. [sess. 
followed by tetanus in a quarter of an hour or more, while 2 centi- 
grms. was a lethal dose. 
The action on rabbits can be seen from the subjoined Table. 
Filehne has stated that benzoylmorphine is a local anaesthetic, 
but after a number of experiments on ourselves and on animals 
we are unable to confirm his results. 
Benzoyl, like acetyl, is an acid radical, and our results seem to show 
that it is of little consequence as regards action which of them is intro- 
duced, so long as they replace the same hydrogen atom in morphine. 
Action of Benzoylmorphine on Babbits. 
No. 
Weight of Rahhit 
in Gnns. 
Dose in 
Grms. 
Dose per Kilo. Body- 
Weight. 
Effects. 
1 
1500 
o-ooi 
0*00066 
Lay for 2J hours as if gently asleep ; respira- 
tion fell from 17 to 10 per 10 seconds. 
2 
1304 
0*005 
0*0039 
Lay as if asleep for 6 hours. Was a good deal 
narcotised, but could always be easily roused. 
In 5 minutes respiration fell from 16 per 3 0 
seconds to 11, and in 11 minutes to 3. 
3 
1560 
o-oi 
0*0064 
Was deeply narcotised for 6 hours. Respira- 
tion rapidly fell from 24 to 2 in 10 seconds. 
No increase reflexes. 
4 
1560 
0*1 
0-064 
Was at first much narcotised, but in 20 minutes 
reflexes had greatly increased and in 27 
minutes had tetanus. After lasting for 
about 6 hours, the tetanic condition passed 
off, but the animal remained deeply nar- 
cotised for many hours afterwards. 
Dibenzoylm orphine. 
10 grms. of anhydrous morphine and 20 grms. benzoylchloride 
were together heated in a sealed tube placed in a water-bath for 
seven hours. The contents of the tube were then evaporated, the 
residue treated with hot water, and excess of ammonia added. The 
whole was now shaken up with chloroform, and the latter evapor- 
ated. There were no signs of crystallisation ; wherefore the sub- 
stance was dissolved in ether, and the ether driven off, but the solu- 
tion refused to crystallise. Its chloroplatinate, dried at 140° C., 
was ignited. '2565 grm. gave *0365 grm. Pt. = 14*23 per cent. 
2[Ci 7 Hi 7 (C 7 H 5 0) 2 N0 3 -HCl]PtC] 4 = 14*03 percent. Pt. 
