1889-90.] Mr Dott and Dr Stockman on Morphine. 357 
of spinal cord, just as we found small doses of morphine or codeine 
to do. We found 2 centigrammes and upwards to be a lethal dose 
for frogs. The heart heats well long after paralysis is completely 
developed. 
Rabbits. — On rabbits methylmorphium chloride has the same 
action as on frogs, but owing to their higher organisation the details 
cannot be worked out in the same complete manner. When 2J to 
5 centigrammes are given subcutaneously drowsiness and narcotism 
ensue, apparently without any paralysis of motor nerves. With 
larger doses there is marked narcotism, probably some depression of 
motor nerves, and a tendency to increased reflex which is never 
very pronounced. Probably it is obscured by the depression of the 
motor nerves. As soon, however, as the dose is large enough to 
paralyse the motor nerves death occurs rapidly from asphyxia. 
The blood-vessels in ears were seen always to dilate enormously. 
Expt. 21. — Rabbit, 1653 grms. H., 32; R., 26 in 10 seconds. 
12.4. — 0'3 methylmorphium chloride subcutaneously. 
12.13. — Gait less steady. H., 33; R., 24. 
12.19. — Lying down. Trembles, and occasionally gives a slight 
start ; starts if tapped or on hearing a noise ; pupils widely dilated. 
12.25. — Very flaccid, but gives occasionally a spasmodic jerk; 
sciatic nerves are much depressed in excitability. H., 28 ; R., 6. 
12.40. — Had an irregular convulsion (probably dyspnoeic, not 
tetanic) ; corneal reflex very sluggish ; pupil dilated ; sometimes 
gives a violent start on stimulation. 
1.5. — Sitting up. H., 27 ; R., 14. Increase in reflexes has com- 
pletely passed off ; . still drowsy. 
5.0. — Has gradually recovered. 
Expt. 22. — Rabbit, 780 grms. H. 28; R., 23 in 10 seconds. 
2.36. — 0’5 grm. subcutaneously. 
2.39. — Chin fallen on table; pupils smaller. R., 12. 
2.40. — Lies in any position as if deeply narcotised; gives oc- 
casionally a start. 
2.42. — R. is difficult; pupil very small; cyanosed. 
2.43. — Died quietly. The motor nerves were found inexcitable 
to electric stimulation, otherwise nothing remarkable. 
The minimum lethal dose seems to be about 3 decigrammes for 
medium-sized rabbits, about the same as the lethal dose of morphine, 
