358 P roceedings of Royal Society of Edinburgh. [sess. 
but its tendency to paralyse motor nerves probably makes it some- 
what more deadly. 
Action of Methylmorphium Chloride on Rabbits. 
No. 
Weight of Rabbit 
in Grms. 
Dose in 
Grins. 
Dose per Kilo. Body 
Weight. 
Effects. 
1 
1680 
0*025 
0*015 
Slightly drowsy for 2| hours. 
2 
Same 
0*05 
0*03 
Was drowsy for more than 4 hours. Respiration 
fell in 42 minutes from 23 to 12 per 10 seconds. 
3 
1680 
0*1 
0*06 
Drowsiness and weakness of gait in 8 minutes, 
and lay down. In 38 minutes there was slight 
increase in reflexes, which soon passed off, and 
animal remained drowsy all day. 
4 
1790 
0*2 
0*112 
Drowsy all day. 51 minutes after administra- 
tion there was slight increase of reflexes, which 
soon passed off. 
5 
1160 
0*2 
0*172 
About same as Experiment 7. 
6 
1790 
0*3 
0*167 
Same symptoms as in Experiment 7, but died in 
1 hour 40 minutes from paralysis of motor 
nerves. 
7 
1653 
0*3 
0*180 
Experiment 21 in text. 
8 
Same 
0*5 
0*302 
Same as in Experiment 9. 
9 
780 
0*5 
0*65 
Experiment 22 in text. 
From the foregoing experiments it is obvious that the addition of 
a molecule of methylchloride to morphine does not alter its physio- 
logical action so profoundly as has been stated. The paralysing 
action on motor nerves is considerably increased and the narcotic 
action is lessened, but qualitatively its effects on the animal organism 
remain similar to those of morphine. 
Looking at the matter from a chemical point of view, this is what 
one would expect. Here, just as in the case of methylmorphine or 
acetylmorphine, &c., we have not made any profound chemical 
change in the intimate structure of the morphine molecule. We 
have simply added on a radical to one of its outlying groups, and 
although the addition has altered the quantitative action it has 
left untouched the qualitative. 
Methylcodeium Sulphate. 
Equivalent quantities of codeine and iodide of methyl dissolved 
in rectified spirit were heated in the water-bath in a sealed tube 
