1889 — 90 .] Mr Dott and Dr Stockman on Morphine. 
361 
3.40. — Appearance and attitude normal. Reflexes are very 
slightly increased. 
4.20. — Reflexes increased. 
Next day there was still a slight increase of the reflexes. 
When such a dose as 1 centigramme is given the motor nerves 
are much depressed in excitability but seldom completely paralysed. 
Expt. 24. — Frog, 28 grms. R., 23 in 10 seconds. 
12.50. — 0'01 methyl-codeiuni sulphate subcutaneously. 
1.0. — General paralysis has gradually come on. Crawls about 
with great difficulty. R., 9. 
1.20. — Much worse. No response to severe pinching of toe. 
Both sciatic nerves are excitable at 190 mm. Electrodes placed 
over spine anteriorly (near head) cause contraction of both legs. 
2.0. — Sciatics excitable at 80 mm. 
3.0. — Has recovered somewhat. Both sciatics excitable at 
80 mm. 
4.30. — Can now jump and move about. 
Next day. — Slight increase in reflexes. 
After 2 centigrammes and upwards we soon get complete 
paralysis of motor nerves. This, however, wears off very soon, 
and is followed by increase of reflex excitability which sometimes 
amounts to tetanus. 
Expt. 25.— Frog, 28 grms. 
11.40. — 0 - 04 grm. methyl-codeium sulphate subcutaneously. 
12.40. — Quite flaccid. On stimulating sciatic nerves with strong 
current the muscles did not respond. Pupils are mere slits. 
Second day. — Still very flaccid. Sciatics slightly excitable to 
strong current. 
Third day. — Reflexes slightly increased. Sciatic nerves quite 
excitable. 
Fourth to eighth day. — Reflexes have been greatly exaggerated. 
Ninth day. — Tetanus on stimulation. 
Tenth to sixteenth day. — The reflex increase has gradually passed 
off. 
Twentieth day. — Is now quite recovered. 
The amount required to paralyse motor nerves is therefore very 
large, the paralysis soon passes off, and as soon as it has done so 
the increase of reflexes can be, and is, manifested. 
