369 
1889-90.] Mr Dott and Dr Stockman on Morphine. 
than that of morphine. The substance is practically insoluble in 
water and dilute acids, and for our experiments had to be dissolved 
in a small amount caustic soda. 
Frogs. — One centigramme caused lethargy, followed by an increase 
in reflexes. When the dose was increased to 2 centigrammes the 
two stages became very distinct, and tetanus was developed. 
Expt. 29. — Frog, 33 grms. R, 22 in 10 seconds. 
11.38. — 0*02 subcutaneously in solution. 
11.40. — Heavy and sluggish. 
11.46. — Corneal reflex gone. Will not lie on back. 
11.52. — Very heavy and sluggish; jumps very abortive. R, 15. 
Reflexes are greatly diminished. 
12.0. — R. has ceased. Lies in any position. 
12.30. — Reflexes increased. 
12.40. — Gives start on stimulation. 
2.30. — Almost tetanus on stimulation. 
4.0. — Same. 
Next day. — Tetanus on stimulation. 
Larger doses were fatal ; the narcotic stage is not very deep and 
tetanus soon supervenes, followed by exhaustion. 
Rabbits. — As we had only a small quantity of the substance, we 
made only four experiments on rabbits. The result showed that 
its narcotic power in rabbits is very much less than that of morphine. 
We had not sufficient to test its tetanising power. 
The experiments are given in the following table : — 
Action of Morphine Sulphuric Acid Ether on Rabbits. 
No. 
Weight of Rabbit 
in Grms. 
Dose in 
Grms. 
Dose per Kilo. Body 
Weight. 
\ Effects. 
1 
1000 
0-02 
0-02 
Scarcely any effect. Was a little quieter for 
about 2 hours, during which respiration fell 
from 19 to 12 per 10 seconds. 
2 
1000 
0-04 
0-04 
Was distinctly lethargic for 3 hours, but hardly 
amounting to narcosis. 
3 
1412 
0-05 
0*035 
Same as Experiment 2. 
4 
1412 
01 
0*07 
Was much quieter for 3 hours. Respiration fell 
from 16 to 9 per 10 seconds. Narcotic effect 
very slight. 
2 A 
YOL. XVII. 
26/9/90 
