1889 - 90 .] Mr Dott and Dr Stockman on Morphine. 371 
off, leaving only tetanus. The same tiling has been noted as occur- 
ring with morphine. 
The following experiment will serve as an example : — 
JSxpt. 30. — Frog, 27 grms. 
1.50. — 0*005 chlorocodide subcutaneously. 
2.0. — Pupils very small ; respiration ceased ; reflexes dull. Lies 
on back if turned over, struggles if pinched. 
2.7. — Spinal reflexes now a good deal increased ; no corneal 
reflexes. 
,2.10. — Least touch causes violent jerk, but frog lies quite ex- 
hausted and flaccid after it. Pupils are mere slits. 
3.30 — Same. 
5.30. — Gives faint tetanic jerk when stimulated. 
Second day. — Reflexes greatly increased. 
Third day. — Greater increase reflexes. 
Fourth day. — In violent tetanus. 
When a larger dose, such as 1 centigramme, was given, there was 
great depression of the cord, so much so that only a faint indication 
of the tendency to tetanus was observable in many cases, although 
in others it was well marked. One centigramme by the mouth 
caused well-marked but not extreme depression, followed shortly by 
tetanus. 
Two centigrammes injected into the aorta produced tetanus at 
once. 
The paralysing effect of chlorocodide on motor nerves is about 
equal to that of codeine; 15 milligrammes injected into the iliac 
artery destroyed the electric excitability of the sciatic nerve in a 
few minutes. 
So far the action of chlorocodide closely resembles that of codeine, 
but is more depressing to the spinal cord. In addition, however, it 
is a very decided muscle-poison. When injected subcutaneously 
the muscles in the immediate neighbourhood very soon become 
poisoned and cease to respond to electric stimuli, while those at a 
distance seem to be little affected. 
The heart also is very much depressed. 
In frogs 1 centigramme sooner or later proves fatal. 
Rabbits. — In rabbits doses of 2-5 centigrammes caused marked 
weakness in legs, depression of the spinal cord, slow and weaker 
