372 
Proceedings of Royal Society of Edinburgh. 
action of the heart, and a great inclination to lie down. There was 
no narcosis. 
When larger doses, up to 1 decigramme, are given, the depression 
of the spinal cord is extreme, hut there is also a tendency to tetanic 
jerking. The symptoms are exactly as if a spinal stimulant and 
depressant had been given together. 
When still larger doses are given tetanus of a very decided 
character is seen, hut towards the end of the poisoning becomes very 
feeble owing to the marked weakness of the whole muscular system. 
The following experiments show the action of large doses: — 
Expt. 31. — Rabbit, 1800 grms. 
12.5 — 0T5 grm. chlorocodide subcutaneously. 
12.12. — Legs weak, gait affected. 
12.14. — Cannot walk ; occasionally gives slight start. 
12.16. — Tetanic attack with opisthotonos. 
12.18. — Clonic spasms. 
12.35. — Has had frequent clonic spasms not amounting to 
tetanus. 
I. 10. — Increased reflex passing off; legs very weak; has to lie 
down. 
3. 0. — Is recovering ; can drag itself about. 
4.20. — Nearly well. 
Expt. 32. — Rabbit, 1760 grms. 
II. 44. — 0 - 2 grm. chlorocodide subcutaneously. 
11.48. — Slight tetanus ; can still walk. 
11.54. — Severe tetanus, succeeded by very great flaccidity and 
depression. 
11.59. — Lying flaccid, and evidently suffering from muscular 
weakness. Occasionally gives a slight start. 
12.15. — Same. 
12.40. — Has frequent clonus of head ; the rest of body less 
affected. 
12.55. — Tendency to spasm much greater. The jerkings are 
almost continuous. Had one severe tetanic spasm with opisthotonos. 
1.55. — Has been in almost continuous clonic spasms. 
2.50. — Died quietly. 
Post-mortem immediately. — Heart stopped ; not excitable to electric 
stimulation ; peristalsis good ; the voluntary muscles all over the 
