1889 - 90 .] Mr Dott and Dr Stockman on Morphine. 
375 
1.10. — Slight increase in reflexes. 
1.20. — Reflexes greatly increased. 
I. 45. — Motor nerves much depressed in excitability. Reflex 
increase can scarcely he manifested. 
2.15. — Motor nerves paralysed. 
3.0. — -Muscles of hack paralysed and not excitable to interrupted 
current ; other muscles of body excitable ; heart still heating. 
Rabbits. — In rabbits 1-4 centigrammes caused slight narcosis, 
and very slight tendency to increased reflexes. Respiration 
diminished greatly in frequency, and the heart slightly. 
Doses of from 8-25 centigrammes caused varying degrees of 
increased reflex without marked narcosis. The larger the dose the 
less tendency there was to narcosis, hut the more to paralysis of 
motor nerves with consequent paresis and depression. 
Expt. 35. — Rabbit, 1635 grms. H., 32; R., 22 in 10 seconds. 
II. 50. — 025 trichloromorphide subcutaneously. 
11.56. — Has lain down. R., 7 ; H., 31. Ears very hypersemic. 
12.0. — Legs very weak; slight increase in reflexes. H., 30; 
R., 7. Pupils larger. 
12.5. — Reflexes markedly increased, hut there is also very con- 
siderable paralysis. Pupils widely dilated. 
12.12. — Slight tetanic attack. 
12.35. — Lying on belly; every few seconds gives a spasmodic 
twitch. R., 7. 
2.50. — Has been much in same condition. There has been no 
narcosis. 
5.0. — The increase of reflexes is wearing off, hut there is still 
great depression. 
7.0. — Increased reflex^ gone. 
8.0. — Still great depression. 
Next day was quite well. 
In this experiment, as in others with large doses, it was evident 
that the partial paralysis of the motor nerves prevents the full 
manifestation of the tetanus, and probably thereby prevents death 
from convulsions. 
The action of trichloromorphide resembles qualitatively that of the 
other morphine derivatives ; its action on motor nerves is markedly 
paralysing, and it is in addition a not very powerful muscle poison. 
