376 
Proceedings of Royal Society of Edinburgh. [sess. 
Nitrosomorphine. — C 27 H 18 (N0)N0 3 .H 2 0. 
This compound was prepared by E. L. Mayer by passing nitrous 
fumes (prepared by action of nitric acid on arsenious acid) into a 
solution of morphine. The composition indicated is the same as 
that of morphine nitrite, and there seems to be some little doubt 
as to the purity of the substance. 
Physiological Action of Nitrosomorpliine. 
Nitrosomorpliine is a very insoluble substance, and we had 
difficulty in getting a proper solution for subcutaneous injection in 
frogs. We therefore gave it by the mouth in substance. When 
0 - 015 grm. was so given, the animal gradually developed a narcotic 
condition, followed in due time by increase of reflexes and tetanus. 
In rabbits 4 or 5 centigrammes subcutaneously caused light 
narcosis, lasting four or five hours. We found it difficult to give 
larger doses. 
These experiments, although not very satisfactory, show that 
nitrosomorphine has the same qualitative effect as morphine. 
Physiological Action of some other Morphine Derivatives. 
C. R. A. Wright prepared a number of morphine derivatives 
which were examined by M. Foster and by R. Stocker. 
Deoxymorphia. — ^C l7 H 19 N0 2 (C l7 H l7 N0^- 
Deoycodeia. — C 18 H 21 , N 0 2 . 
With these substances Foster found that 5 centigrammes caused 
in cats excitement, while 1 decigramme caused convulsions and 
excitement. 
Bromotetramorphia. — C 68 H 75 BrN 4 0 12 (4 molecules of morphine 
coalesced together and one H. replaced by Br.). 
Bromotetracodeia . — ^72^-83-^ r ^4^12* 
Ghlorotetracodeia. — ^72®83^^4^12* 
These all acted in same way. The hydrochlorates were used. 
In cats 1 decigramme caused excitement and symptoms similar 
to morphine. In rabbits the same amount caused only slight 
excitement. 
Stocker experimented with dicodeia (2 molecules of codeine 
