IS BULLETIN 131)1, U. S. DEPARTMENT OF AGRICULTURE 
secretion. This was frequently associated with the presence of 
considerable zymogen in the acinar cells. 
Summarizing this work, it appears that the most noticeable 
changes were degeneration and fat accumulation in the liver paren- 
chyma with degeneration of the bile ducts and gall bladder; well 
marked, but not extreme, parenchymatous nephritis in the kidneys, 
and degenerative changes in the red blood corpuscles. In the heart 
muscle there were less severe degenerative changes than in the pre- 
ceding tissues. The changes in the walls of the alimentary tract 
were mild in character but indicated the presence of a mild irritant. 
The changes in the other organs were apparently secondary in char- 
acter to those indicated. 
TOXIC DOSE FOR SHEEP 
In a discussion of the toxic and lethal dosage, inasmuch as the 
figures are based on the green weight of the plant, it is necessary 
to consider the loss of moisture in the drying of the plant. The 
last two cases, sheep Nos. 716 and 743, were given plants collected 
in May, when the loss in drying w T as 75 per cent. The rest of the 
experiments were with plants collected in the fall and early winter 
when the loss by drying was 50 per cent. 
Of all the cases of poisoned sheep in which the fall and early 
winter plants were used the smallest dosage was 6.25 pounds per 
100 pounds of animal in sheep No. 657. This was given by balling 
gun in a single day, but the symptoms did not appear until four 
days later. The largest quantity necessary to produce symptoms 
was 36.82 pounds per 100 pounds of animal in the case of sheep No. 
576, the feeding being extended over 29 days. The daily feeding 
varied from 0.47 to 6.25 pounds per 100 pounds of animal. This last 
case, however, was exceptional, as the attempt was made to force 
into the animal as large a quantity as possible in one day. The aver- 
age of the other daily feedings was 1.17 pounds per 100 pounds of 
animal. Most of the daily feedings were not far from this average, 
as this quantity was about all that a sheep could take in a single day. 
Averaging all these experimental sheep, the total feed per 100 
pounds of animal to produce illness was 23.25 pounds given in 19.5 
days, the average daily ration being 1.19 pounds. 
Put in a general way, sheep are poisoned on a daily feeding of 
about 1.25 pounds per 100 pounds of animal continued for about 
three weeks, although they may be poisoned in a week or less. 
TOXIC AND LETHAL DOSAGE 
In Table 3 are gathered together the data in regard to the toxic 
and lethal doses for the animals which were affected by the plant. 
None of the experimental sheep which received 1.5 pounds per 
100 pounds of animal daily failed to be poisoned, with one excep- 
tion: Sheep 495 received 1.9 pounds daily for 51 days with no 
symptoms. This animal was kept constantly in good pasture. 
Of the two sheep, Nos. 716 and 743, poisoned on the spring plants, 
the average to produce illness was 48 pounds per hundred weight of 
animal given in 25 days, with an average daily dosage of 1.9 pounds. 
Reduced to dry weight, this would be 12 pounds and an average 
daily dosage of 0.475 pound given in 25 days. A similar reduction 
to dry weight of the cases fed on fall and early winter plants would 
