MEXICAN WHORLED MILKWEED AS A POISONOUS PLANT. 11 
change had occurred in the epithelial cells of the convoluted tubules 
and consisted of cloudy swelling. Other cells were present, singly 
and in groups, the cytoplasm of which had an unusual affinity for 
eosin. Such cells contained shrunken nuclei which stained darker 
and more uniformly than normal. Other nuclei were very faint or 
had entirely disappeared. The lumina in may places contained a 
considerable quantity of disintegrated cytoplasm and sometimes 
free epithelial cell nuclei. In congested areas frequently epithelial 
cells of the tubules contained considerable brownish granular pig- 
ment. Granular material, pigment, and an abnormal number of 
leucocytes were found in some veins. Some distended capillaries 
in the sections from the kidneys of Sheep 595 were occupied by 
hyalin areas which stained strongly with eosin. 
Other tubules than the convoluted, as the ascending limb of Henle, 
showed similar though less pronounced changes. 
Heart. — The myocardium of the left ventricle showed changes like 
those occurring in some of the A. galioides cases, but were not so 
marked. In many areas the capillaries were distended with blood 
and very prominent between the muscle fibers. The tissue was 
mildly edematous. In most areas the muscle fibers had a less dis- 
tinct cross-striated appearance and a more granular cytoplasm than 
normal. A few minute hemorrhages appeared. Very few leuco- 
cytes were present. The red blood corpuscles stained well and ap- 
peared to be normal. 
Lungs. — There was a mild inflammation of the lungs. The capil- 
laries were engorged and distended, in many places nearly filling 
the alveoli. Numerous leucocytes, mostly polymorphonuclear, 
were scattered throughout the tissue. Many epithelial cells of the 
alveoli appeared swollen or vacuolated and their nuclei were irregu- 
lar in outline. The epithelial cells of the bronchioles were swollen or 
in the process of disintegration, the bronchioles containing much 
granular material, many nuclei of exfoliated cells, and sometimes 
erythrocytes. 
In some veins there were areas composed of normal and pale 
erythrocytes, much finely granular material, and a considerable num- 
ber of leucocytes, mostly polymorphonuclear. A considerable quantity 
of brownish pigment was distributed throughout the sections. 
Thyroid. — Little that was abnormal was found in the thyroid 
glands. This organ was not congested in either animal, though 
some brownish pigment and pale erythrocytes were found. In a 
few capillaries the erythrocytes appeared to have fused, forming 
hyalin thrombi. In the A. galioides cases this gland was almost 
always severely congested. 
Thymus. — Congestion had occurred in the thymus in each of the 
two sheep, though this was most pronounced in the thoracic portion 
of the gland of Sheep 595, where extensive hemorrhage into the 
