POISONOUS PROPERTIES OF THE WHORLED MILKWEED. 7 
Table 3. — A. pumila — Duration of sickness in cases of recovery . 
Designation of 
animal. 
Duration of symptoms. 
Designation of 
animal. 
Duration of symptoms. 
1 day. 
lday. 
2 days 2\ hours. 
2 days 4 hours. 
7 J hours. 
1 day 1 hour. 
1 day 17 hours. 
2 days 4J hours. 
Sheep 482 
Sheep 546 
3 days 9J hours. 
Sheep 512 
Sheep 520 
1 day. 
Sheep 539 
Sheep 539 
1 day 8 hours. 
Sheep 516 
4 days. 
Sheep 516 
Sheep 542 
5 days. 
Sheep 547 
It will be noticed that the symptoms continued from a minimum of 
"k\ hours to a maximum of 5 days. With the exception of Sheep 539 
the dosage was gradually increased in the order of the table. While 
there was no exact relation between the size of the dose and the dura- 
tion of the symptoms, in a very general way the greater doses caused 
the more prolonged symptoms. 
Of the two animals that died, death followed in Sheep 519 in 32 
hours, and in Sheep 547 in 38 hours. 
AUTOPSIES. 
The findings from the post-mortem examinations of the two cases 
that terminated in death were not very positive. In each case the 
animal was bloated and there was some gas in the alimentary canal. 
However, so far as appeared without microscopic examination, there 
were no clearly marked lesions in any of the organs. 
MICROSCOPIC CHANGES IN TISSUES OF SHEEP KILLED BY "ASCLEPIAS PUMILA." 
Liver. — The hepatic cells in the two fatal cases were swollen so as to 
crowd the blood largely out of the capillaries. Cloudy swelling was 
pronounced in the liver of Sheep 547, the cytoplasm of the hepatic 
cells being very granular and having a ground-glass appearance, 
which made it difficult to make out fine details. This condition was 
not so well advanced in Sheep 519. The blood in many veins con- 
tained much hemosiderin pigment, areas of granular material, pieces 
of degenerated hepatic cells, and sometimes portions of epithelium 
from the walls of the veins. Some of the veins were engorged, others 
not. The bile ducts were often catarrhal. The changes in the hepatic 
cells in both animals, especially in Sheep 547, were more pronounced 
than in the A. galioides cases. 
Kidneys. — The changes were practically like those found in the 
A. galioides cases, consisting of areas of congestion and edema and a 
swollen and somewhat degenerated condition of the epithelium, par- 
ticularly in the convoluted tubules. In many tubules the lumina were 
practically filled by the swollen cells. Other cells were degenerated 
and partly disintegrated. Most nuclei stained well; a few stained 
