8 BULLETIN 942, U. S. DEPARTMENT OF AGRICULTURE. 
very faintly, while others were wrinkled. In the congested areas there 
were deposits of hemosiderin pigment, much of it being in tubule 
epithelial cells. Apparently pronounced hemolysis occurred. 
Heart. — This tissue was mildly congested in some areas in Sheep 
547, and a few minute hemorrhages occurred. In both animals the 
cross-striated appearance was less pronounced than usual, especially 
in areas where the cytoplasm was more granular than normal. This 
was less marked than that found in some of the A. galioides cases, but 
was not materially different and probably was the result of excessive 
activity of the cardiac muscle. 
Lungs. — The sections of the lungs of Sheep 547 showed congestion ; 
those of Sheep 519 did not. In both cases, however, hemosiderin 
pigment was present and thrombi were found in the arteries. While 
these thrombi differed somewhat in detail their origin may have been 
and probably was the same. The fact that they were found in arteries 
indicates that they were embolic in nature and possibly originated in 
the liver. 
Thyroid. — The thyroid from each animal appeared to be normal 
except for a possible slight increase in connective tissue in Sheep 540, 
which had no connection with the A. pumila poisoning. In the A. 
galioides cases the thyroid tissue was congested. 
Thymus. — The thymus from Sheep 547 was the only one examined. 
It was severely congested and was hemorrhagic as well as edematous. 
The medullary portion of the lobules was especially full of blood. 
No changes of importance were noted in the lymphoid cells, though 
in places large cells with finely granular cytoplasm, apparently 
phagocytic in nature, were present. 
Nervous system. — The pronounced congestion noted in various 
parts of the nervous system in the A. galioides cases was absent in 
both the sheep poisoned by A. 'pumila, though all portions examined 
were somewhat edematous. In the lumbar cord of each case, and in 
the cerebrum and the cerebellum of Sheep 519, a small amount of 
diapedesis of erythrocytes had occurred. The nerve cells of the 
medulla and spinal cord and the Purkinje cells of the cerebellum in 
both cases had undergone marked changes. The Purkinje cells of 
sheep poisoned with A. galioides were found to show marked, or in 
some cases, extreme fatigue effects. Changes in other nerve cells 
were apparently fatigue effects. 
Thrombi were found in the meninges and sometimes in the nervous 
tissue. Some of these contained fibrin, others appeared hyalin. 
Alimentary canal. — The only portion showing changes which may 
be considered due to the A. jiumila was in the ileum and suggested 
the presence of an irritant. The ileum of Sheep 547 was mildly con- 
gested, and hemorrhages had occurred. In the mucosa was an ab- 
normal number of mononuclear leucocvtes. A similar invasion, but 
