FATTY DEGENERATIONS. 
199 
is replaced by adipose tissue ; in this case the disease 
no doubt first commenced in early life, and as the 
fasciculi diminished in size, the adipose tissue was de- 
posited to occupy their place, forming a good instance 
of fatty substitution. A portion of a fasciculus, sur- 
rounded by adipose cells, is represented in Fig. 150, B, 
and an entire fasciculus, full of nearly equal-sized 
globules of oil, in Fig. 150, A. 
The leg of a man thirty-five 
years of age was removed a few 
months since at King’s College 
Hospital, by Mr. Partridge, in 
which all the muscles had been 
replaced by adipose tissue. The 
limb had been rendered useless 
by an attack of paralysis, oc- 
curring three years after birth. 
Only a few fasciculi could be 
discovered amongst the adipose cells, and these were of 
very small size and perfectly healthy. Fatty degenera- 
tion appears also to occur in osseous tissues, and indeed 
the disease termed mollifies ossium is of this nature. 
All bones so affected have thin walls, are always more 
or less soft, and contain an abundance of oil. I have 
examined the bones in several cases, and found that 
the disease first commences in the bone cells, the cell 
itself becoming larger and larger, its canaliculi dis- 
appearing, and several of these cells uniting to form a 
cavity, in which oil globules soon make their appearance, 
FIG. 150. 
A B 
a, fatty degeneration of 
voluntary muscle, b, substi- 
tution of adipose tissue for 
voluntary muscle. 
