THE WOOLLY-POD MILKWEED. G 
change. Of these 3 only 1 was distinctly poisoned. Four animals 
exhibited a more or less distinct rise in temperature. Of these 4, 
2 had only symptoms of poisoning. Eleven of the eighteen cases had 
a lowered temperature after the feeding. This was “most marked in 
sheep 680, 663, 664, 695, 691, and cattle 928. The lowest temperatures 
/ noted were 98° F. in cattle 928, 99° in sheep 663 and 664, and 97° 
in sheep 695. 
_ This lowered temperature was ordinarily followed by a period of 
| high temperature. The highest noted were 103.6° in sheep 668, 
- 104.5° in sheep 695, and 105.4° in sheep 691. Figures 6 and 7 ilus- 
trate this in the temperature curves of sheep 691 and 695. It may 
be noted that the low temperatures were distinctly subnormal, while 
the higher temperatures can not be considered as abnormal, although 
they were higher than the average temperatures of the animals. 
The temperature picture was not of an entirely uniform character, 
but in most cases three phases could be more or less clearly distin- 
guished. Within 24 hours after a feeding there was a fall in tem- 
perature to a point in most cases clearly subnormal. This was 
followed, generally within a 24-hour period, by a time in which the 
temperatures were slightly higher than normal. In the third period, 
in which normal temper ature was gradually restored, there was fre- 
quently an unusual degree of diurnal variation. It is in the second 
period that the animals are most likely to suffer from diarrhea, and 
that condition may account to some extent for the slightly higher 
temperature. 
In general, the course of symptoms was about as follows: The 
first symptom was depression accompanied by a rapid and ordinarily 
weak pulse and a lowered temperature. These symptoms appeared 
several hours after the administration of the plant—sometimes as 
long after as 24 hours. In severe cases there was dyspneea, groaning, 
and some evidence of pain, followed by a period of higher tempera- 
ture and inflammation of the alimentary canal, resulting i im a more 
or less clearly marked diarrhea in which the feces showed mucus and 
sometimes blood. The animals which died grew gradually weaker. 
with no other marked symptoms, and died quietly with no spasms 
and no period of coma. Recovery in all cases was a slow and gradual 
process, sometimes requiring a week. 
DELAY IN DEVELOPMENT OF SYMPTOMS. 
In Table 2 is shown the time which elapsed between the feeding 
of the plant and the development of symptoms. As sheep 572 was a 
~ somewhat doubtful case with a single observation only, it is not 
included in the table, nor in Table 3. 
The time in the case of the two cattle used was nearly the same, 
averaging 21 hours and 36 minutes. In the sheep the minimum was 
3 hours 23 minutes and the maximum 22 hours 35 minutes. The 
average time did not differ much from that of the four species of 
