THE WOOLLY-POD MILKWEED. 1] 
TABLE 4.—Duration of sickness in fatal cases. 
Animal. Duration of symptoms. 
Sheep: Days. Hours. | Minutes. 
NO ieee ee St 2S eee a ee a 1 3 48 
298 GEE see bee ee oka Se ee ae ee en ee ae a 15 15 
INT SUD one ees eee Jee ee ene ee eae 6 Dee, |e agers 
SU NCW ites Se) Seon Sg se 25 oe Re ee ee ee ee 9 50 
is a long time for the effect of a single small dose of a poisonous 
substance to continue. It shows that the plant produces a profeund 
effect upon the system. 
AUTOPSY FINDINGS. 
Autopsies were made on five sheep. In each there was congestion 
in the fourth stomach and ileum. In single cases there was some 
congestion in other parts of the alimentary canal, for example, in 
rumen, reticulum, and cecum. The lungs were congested in four 
cases and the kidneys in three. It will be seen that the picture was 
not especially characteristic. 
In general, the lesions consisted of congestion of the lungs, kid- 
neys, and portions of the alimentary canal, the last being most 
marked in the duodenum. 
MICROSCOPIC CHANGES IN TISSUES. 
The microscopic examination of the tissues brings out in greater 
detail the changes which were noted in the autopsies and presents 
certain additional facts. 
Many portions of the alimentary tract were affected. In the 
mucosa of various parts of the small intestines there was an edema- 
tous condition, and, in all cases examined, lymphocytes and some- 
times polymorphonuclear leucocytes were much more abundant than 
normal. 
In the wall of the fourth stomach an outwandering of leucocytes 
had occurred. This was especially noticeable near the border line 
between the mucosa and the submucosa. In this region, too, the 
blood vessels were somewhat distended. This condition was less 
marked in the cases of short illness, but in sheep 695, which lived 
for nearly eight days, it was very pronounced and the submucosa 
was greatly thickened by a serious exudate. 
The wall of the second stomach was thickened in two of the cases. 
In the case of shorter illness the epithelial cells of the mucosa were 
swollen, a great proportion of them necrotic, and the area infiltrated 
with leucocytes. In the connective tissues there was pronounced 
edema. In the more prolonged case the mucosa and submucosa were 
represented by a greatly thickened mass of granular débris. The 
muscle layers were also thickened, the muscle “bundles being pushed 
apart by the tremendously distended and ruptured blood vessels and 
the marked accumulations of serum and leucocytes. 
A somewhat similar condition was found in the first stomach of 
one case and the third stomach of another. 
