12 BULLETIN 1212, U. S. DEPARTMENT OF AGRICULTURE. 
Of the glandular organs, the kidneys were the most severely af- 
fected, the conditions being of the acute parenchymatous nephritis 
type. The convoluted tubules w ere the most severely attacked. In 
one case few nuclei were apparent in epithelial cells of these tubules. 
In the case of sheep 695 there were numerous casts in the collecting 
tubules, and most of the tubules of the medullary rays were oreatly 
distended, the distension giving the epithelial cells a flattened ap- 
pearance. The epithelial “cells “lining the capsule of Bowman and 
covering the glomerular tufts were ‘swollen and in some instances 
had undergone marked granular degeneration. 
In the liver the changes in the hepatic cells, as a rule, were not 
very severe. The cytoplasm was somewhat more granular than 
normal and an occasional cell apparently was necrotic. The bile 
i ducts, especially the larger ones, had a swollen epithelium. The 
cells were more or less loosened from the basement membrane, and 
il many of them were necrotic. Cells and groups of cells frequently 
were lying in the lumen of the duct. In many cases the capillaries 
| surrounding the ducts were distended and the neighboring tissue 
I edematous and infiltrated with leucocytes. The interlobular portal 
i sheaths were edematous and in some areas were richly infiltrated 
i with leucocytes. 
, Lymph glands in different parts of the body were affected. 
The branched reticular cells of the lymph spaces were uniformly 
M swollen and often contained an abundance of granular material. In 
| the lymph spaces, swollen and degenerated large mononuclear cells, 
lymphocytes, and sometimes polymorphonuclear leucocytes were 
abundant. Some small-cell groups, apparently of phagocytic cells, 
were necrotic. In most cases the trabecule and capsule were edema- 
tous and infiltrated with leucocytes, many of which were degenerated. 
The glands frequently were congested and some were hemorrhagic, 
the hemorrhages being most abundant in the cortex. 
The spleens of two of the four cases examined were severely con- 
gested and their pulp cells showed marked degeneration. Many 
necrotic nuclei were scattered throughout the mass of red blood 
corpuscles. 
While no marked changes were apparent in the asdte cells of the 
heart, there was a gener ‘al edematous condition of the connective- 
tissue areas. In many places round-cell infiltration had occurred. 
While these cells were most plentiful in the areas where connective 
tissue is most abundant, in some places they were lying between the 
muscle fibers in considerable numbers. 
The arteries and to a less extent the veins of the lungs contained 
an excess of blood in which small aggregations of leucocytes were 
sometimes present. While in some small, restricted areas the pul- 
monary capillaries were distended with blood, as a rule they were 
more or less contracted. 
In summarizing the findings of the autopsies and microscopic 
studies, it appears that the most outstanding features are the evi- 
dences of irritation in various parts of the alimentary tract and in 
the kidneys. This condition was very severe in the w all of the second 
stomach of two of the cases, and in the third stomach of one, and 
appeared in a milder form in the fourth stomach and the small in- 
testines of all. The changes were somewhat severe in the kidneys and 
