34 
BULLETIX 800, IT. S. DEPARTMENT OF AGRICULTURE. 
Table 3. — Time elapsed between feeding of plant and development of symp- 
toms — Continued. 
Animal. 
Date and hour of feeding. 
Date and hour of symptoms. 
Time 
elapsed 
before 
symp- 
toms. 
1918. 
Sheep 478 
Sheep 480 
Sheep 483 
Sheep 492 
Sheep 506 
Sheep 506 
Sheep 509 
Sheep 437 
1919. 
Sheep 372 
Sheep 461 
Sheep 522 
Sheep 522 
Sheep 534 
Sheep 542 
September 5, 2.30 p. m 
September 6, 11.35 a. m. . 
Hours. 
21 
June 18, 2.58 p. m 
2\ 
20 
August 22, 11.10 a. m 
September 11, 4.10 p. m 
September 12, 7.50 a. m. . . . 
September 11, 4.15 p. m 
September 12, 9.30 a. m 
17 
September 20, 5.05 p. m 
September 21, 3.18 p. m... 
22 
June 22, 11.10 a. m. to (?) 
June 23, 8.30 a. m.. : 
September 17, 7.40 a m. 
21? 
September 16, 4.25 p. m 
15 
September 10, 6 p. m 
15 
September 6, 6.15 p. m 
13£ 
September 12, 8 40 a m.. . 
13f 
131 
September 22, 5.18 p. m 
September 23, 7.40 a. m 
August 30, 6.30 p. m 
September 3, 6.25 p. m 
September 4, 7.10 a. m 
12| 
It may be seen from the table that in 1918 it was about 14 hours 
after the horse had finished eating the plant before symptoms 
appeared. 
In the feeding of the horse in 1919 it is not known when the feed- 
ing was completed, but apparently the symptoms of intoxication ap- 
peared in a shorter time. 
Steer 750 was fed the first time about 12.05 p. m., and the first 
symptoms were noted about 9.13- a. m.. the next day, a period of 21 
hours. Xo note was made, however, of the time when the steer fin- 
ished eating the plant, and it may be assumed that the period before 
evidence of intoxication was not more than 18 or 19 hours. At the 
second feeding there were symptoms in 15f hours after the feeding 
was finished. 
In the case of sheep, information is lacking in regard to the in- 
cipience of symptoms in Nos. 468 and 475 : it is not known when the 
feeding of Xo. 509 was completed. In regard to 14 sheep, however, 
notes were taken of the time when symptoms were first manifest. In 
these cases an average of the lapse of time between the feeding and 
the symptoms is 14.1 hours. The shortest time was 2J hours, in the 
case of Xo. 480, and the longest was 22 hours, in the case of No. 506. 
With the exception of Xos 476 and 480 all the cases lie between 15 
and 22 hours. 
One would naturally suppose that the larger doses would take 
effect in the shorter time, and an examination of the cases shows 
that this is true. 
EFFECT OF REPEATED DOSES. 
The repeated feedings which were given to several of the animals 
show significant results in regard to the questions of tolerance, in- 
