625 
Botes, Communications, anb 
IReviews. 
LOUPING ILL. 
[The Society is greatly indebted to His Grace the Duke of 
Northumberland, Iv.G., for his kindness in placing at the disposal 
of the Journal Committee the following interesting and valuable 
report made by Dr. Klein, F.R.S., under the instructions of the 
Duke, into the disease of sheep known in Northumberland, and 
elsewhere in the North, as the Louping 111, this name referring to 
the “ leaping,” or jumping, which characterises the affected animal.] 
REPORT ON THE ETIOLOGY AND PATHOLOGY 
OF “LOUPING ILL.” 
By the invitation and wish of His Grace the Duke of North- 
umberland, I have made an inquiry into the nature of the 
disease known in the north-west of Northumberland as the Louping 
111, and in the following pages I beg to report on the results of this 
inquiry. At the outset I wish to express my obligation to Mr. 
E. G. Wheler, the Duke’s Commissioner, who, with great readiness 
and promptitude, made every endeavour to render this inquiry 
during my stay at Kielder as fruitful as possible. Amongst others 
to whose assistance I am beholden, my acknowledgments are 
especially due to Mr. Walter Iledley of Bewshaugh Farm, from 
whom I not only received most useful and reliable information, and 
his personal assistance in many ways, but who also, at no small 
inconvenience to himself, placed his buildings at my disposal for 
the purpose of making my post-mortem examinations. 
Nature of the disease . — As is well known, the chief and most 
conspicuous symptom of the disease manifests itself in disorder of 
the muscular function of the head and limbs, consisting in abnormal 
contractions, loss of co- ordination of movement, and ultimately in 
loss of movement of the limbs altogether. During the earlier 
phases of these symptoms, which generally repeat themsejves in 
paroxysms, the animals show actual or intended jumping move- 
ments ; hence the popular name of “ Louping 111.” 
With the first onset of the disease the animal is quiet, does not 
feed, and separates from the rest ; it shows at the same time loss of 
muscular power, and periodic contractions (trembling and cramp) 
