146 Proceedings of the Royal Society of Edinburgh. [Sess. 
administered from the following morning onwards. On the third day his 
temperature rose only to 100°, 
and he had no further fever. 
Fig. 2 shows the tempera- 
ture chart of Pte. E. S., and 
illustrates a case unsuccess- 
fully treated by harmaline. 
Harmaline may in this case 
have somewhat allayed the 
fever, but it did not do so 
completely, whereas the sub- 
sequent administration of 
quinine quickly brought down 
the temperature. 
These experiments show 
that harmaline has a definite 
curative effect in malaria, but 
that in the doses given it is 
not so effective as quinine. 
On the other hand, the results obtained with harmaline were remarkably 
good for a preliminary series, 
if account is taken of the fact 
that one had little previous 
experience of its administration 
or dosage. The results were 
probably better than could have 
been obtained with anything 
except one of the cinchona 
alkaloids. As a comparison be- 
tween harmaline and quinine 
the experiments were favour- 
able to quinine for two reasons : 
in the first place, quinine was 
tried after the patients had had 
harmaline, so that any beneficial 
effects previously produced by 
harmaline told in favour of 
quinine; secondly, the dose of 
quinine was relatively higher, 
for, though harmaline is about four and a half times as toxic as quinine 
Fig. 2. — Temperature chart of a case of Acute Malaria 
unsuccessfully treated by Harmaline. 
Fig. 1 . — Temperature chart of a case of Acute Malaria 
successfully treated by Harmaline. 
