148 Proceedings of the Royal Society of Edinburgh. [Sess. 
No relapse occurred in this time, and he was discharged apparently cured 
on the 30th September. See fig. 3. 
“ 2nd case. H. S.. mixed infection, had suffered eight relapses in 148 days, 
from 6th April to September, though under regular quinine treatment, with 
iron and arsenic. Administration of harmine was commenced towards the 
end of September. The case was kept under observation for 119 days, to 
ref- " Q l 
tof- 
iol~ 
/of- 
, 00 - 
99 - 
i V 
ffa^r-rr^v^- 
•Z6 i S- SO 
5*. 
Fig. 3. — Diagrammatic representation of a case of Relapsing Malaria, treated first by 
Quinine and then by Harmine. 
the 25th January, when he was discharged apparently cured, no relapse 
having occurred during this period. See fig. 4. 
“ In this case it is interesting to note that, though harmine was given 
from the 21st of September, the patient suffered a relapse on the 24th. 
Apparently the amount of harmine present in the circulation was insuffi- 
H.s. (W 
fa- 
res'- 
te£- 
/«/'- 
tod- 
99 - 
*■ •** *» s to /a. U, /tc >8 to iZ 3A *<*■ 39 30 3Z U, 3 C, 39- Ao 
__ — — — — 
Fig. 4. — Diagrammatic representation of a case of Relapsing Malaria, treated first by 
Quinine and then by Harmine. 
cient to prevent the development of the parasites, though later, after regular 
continuous dosage, no relapse occurred. 
“ The third case was one of severe malignant infection with frequent 
relapses. Unfortunately the chart is not available at present, for it was 
sent to the Research Committee and has not yet been returned. The usual 
treatment by quinine and arsenic having failed to prevent the relapses, 
harmine was substituted for it at the end of a relapse. The patient rapidly 
improved, and no relapse occurred for about six weeks. I found him one 
morning suffering from a relapse, and was informed that the supply of 
harmine had become exhausted and that he had had no harmine for about 
a week.” 
