Clark and Smith : Toxicological Studies 
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349 P.M. Wholly paralyzed. 
3.51 P.M. Heart at a standstill. 
3.53 P.M. Received injection of i c.c. atropin solution. 
3.56 P.M. Heart begins to beat slowly and it gradually re- 
sumes its normal action. 
5.45 P.M. Frog 8 appears normal. 
While this frog was wholly paralyzed we bared the sciatic 
nerve and, upon stimulation with an induced current, we obtained 
a normal response, thus indicating that no curare effect was pres- 
ent. Other experiments with Inocybe material gave similar re- 
sults. In some cases the frogs died before the next morning ; 
and in others, recovery seemed to be complete. 
Experiments unth Purified and Unpurified Extracts of Clito- 
cybe illudens 
Experiment 13. May 23. Frog 3 weighed 28 gm. Received 
injection of 1.5 c.c. of unpurified extract at 5.24 P.M. 
5.28 P.M. Paralyzed. 
5.33 P.M. Heart at standstill. 
5.38 P.M. Tested as above indicated ; there was no curare 
effect. 
Experiment 27. May 27. Frog 9 weighed 36 gm. Received 
injection of 1.5 c.c. of purified Clitocybe extract at 12.25 P-M. 
12.30 P.M. Lethargic. 
12.40 P.M. Paralyzed; heart at standstill. 
12.42 P.M. Received injection of i c.c. atropin solution. 
12.50 P.M. Heart beats irregularly. 
5.30 P.M. Frog 9 found dead. 
Conclusions 
It is evident that both Clitocybe illudens and Inocybe infida 
contain material exerting a characteristic muscarin effect when 
tested upon the exposed hearts of frogs and turtles. Further- 
more, this toxic action on the exposed heart is completely over- 
come by the application of atropin sulphate solutions ; an action 
analogous to that with a pure muscarin preparation. For some 
reason, parallel experiments with extracts of Amanita muscaria 
