296 
Proceedings of Royal Society of Edinburgh. [sess. 
REFERENCES. 
(1) Cabot, Clinical Examination of the Blood. 
(2) Ehrlich and Lazarus, Histology of the Blood , Myer’s 
translation, figure 1. 
(3) Gulland, Scottish Medical and Surgical Journal , June 
1902. 
(4) Ewing, Clinical Pathology of the Blood , 1901, p. 112. 
(5) Leishman, British Medical Journal, Jan. 11th, 1902. 
(6) Gulland, Scottish Medical and Surgical Journal , April 
1899. 
APPENDIX. 
We have tabulated a variety of conditions with simply a note of 
the changes seen in one film, and venture to think that some idea 
of the frequency of necrobiotic cells may be indicated in that way. 
For convenience of reference we may recapitulate the appearances 
at different stages of the necrobiotic change, but it must be under- 
stood that these changes are not necessarily synchronous as regards 
the different kinds of cells. 
Polymorphonuclear 
Cells. 
Lymphocytes. 
Eosinophiles. 
. Stage 1. 
Yacuolation of pro- 
toplasm and faint 
staining of gran- 
ules. 
Vacuolation of pro- 
toplasm and fray- 
ing or budding 
of its border. 
Vacuolation of pro- 
toplasm. 
Stage 2. 
Swelling, marked 
vacuolation and 
diffuse pale stain- 
ing of protoplasm. 
Swelling of the 
whole cell, nuclear 
outline lost. 
Scattering of gran- 
ules. 
Stage 3. 
Vacuolation of nu- 
cleus ; disintegra- 
tion. 
Great vacuolation. 
Disintegration of 
protoplasm, then 
of nucleus. 
Breaking up of nu- 
cleus, disappear- 
ance of granules. 
