1898 - 99 .] Prof. Carlier on Changes in Newt's Stomach. 
677 
may even be seen in the act of passing through the nuclear wall 
into the protoplasm, where they ultimately break down. There 
is no evidence of their transformation into zymogen granules as 
ver Eecke (5) would have us believe in the case of the pancreas. 
(3) Newt forty-four hours after food . — (Remains of the worm 
still in the stomach.) (Pig. 3, coloured plate, photo 3.) 
At this stage the cells are much larger, and the gland lumen is 
correspondingly reduced in size. The zymogen granules are 
numerous, though not crowded together ; they are usually of 
medium or small size, the larger ones being most numerous near 
the apices of the cells, though in very many cells it is impossible 
to locate granules of any particular size in any definite part. They 
average 1*2 g in diameter. The cell protoplasm hardly stains at 
all, or exhibits a pale reddish-grey tint, showing that it has taken 
up alkaline material from the blood. 
The nuclei appear extremely wrinkled, and contain very little 
chromatin that has a washed-out appearance, and stains feebly 
blue. Average size of nuclei 8*87 x 11*88 g — i.e. they are con- 
siderably smaller than in the preceding specimens. The lanthanin 
granules are very numerous, of small size, and densely crowded 
together, to such an extent that it is difficult to distinguish 
other nuclear structures. They stain of a deep, dull grey-blue, 
and impart by their number and deep coloration a misty appear- 
ance to the nuclei. Their reaction is changing. The nucleoli are 
frequently of immense size, and may be seen passing through the 
nuclear wall, which closes behind them. When in the nucleus 
they lie in a tiny vacuole free from lanthanin granules. 
At this stage, therefore, the cells have already recovered con- 
siderably from their previous exhausted condition, many new 
zymogen granules have made their appearance, and the nuclei 
exhibit every sign of great exhaustion. Nevertheless, mitotic 
figures may be seen in a few of them. 
(4) Sixty-eight hours after food . — (Worm dissolved, though 
debris and mucus are still found in quantity in the stomach.) 
(Fig. 4, coloured plate, photo 4.) 
The gland lumen is now small, the cells large and crowded with 
big zymogen granules nearly all of one size, averaging 1*5 to 1*7 g 
in diameter. The protoplasm has recovered its pale blue tint, but 
