680 Proceedings of Royal Society of Edinburgh. [sess. 
One hour after food . — The lumen has now become of consider- 
able size, owing to further diminution in the size of the cells, 
which also contain fewer zymogen granules. The protoplasm is 
somewhat ragged-looking, owing to the vacuoles present in it, and 
blue-grey in colour. The nuclei appear somewhat wrinkled, and 
measure 10*19 x 12T4 g on the average. They do not contain 
very much chromatin, but that present is arranged in somewhat 
large karyosomes, which have a washed-out or water-logged ap- 
pearance, and stain of a watery-blue colour. The lanthanin 
granules are not numerous, being often greatly reduced in number, 
and stain of a slaty-violet colour. Nucleoli are being expelled, but 
no mitosis was observed. 
Some cells in this preparation were just beginning to secrete, 
and their nuclei when measured were found to be of considerable 
size, namely, 1T29 x 15*83 g } showing that at a very early stage 
the nuclei increase somewhat in size. 
One and a half hours after food. — (Fig. 6, coloured plate.) — The 
lumen is still larger and the cells further reduced in size, and in 
some cases the zymogen granules have disappeared from the bases of 
the cells. Those present are mostly of small size. The protoplasm 
is in small amount, vacuolated, and of a pale blue-grey colour. 
The nuclei are very irregular in shape, with thick envelopes, and 
measure 10*75 x 10*09 g. The chromatin, arranged in isolated 
rounded karyosomes, is not abundant, and stains of a blue colour of 
moderate intensity. The lanthanin granules are further diminished 
in number, and pale blue-grey. Nucleoli may be seen in process of 
extrusion. Mitotic figures are still visible here and there. 
Two and a half hours after food . — The lumen is of about the 
same size as in the last specimen. The cells are shrunken, and 
contain fewer granules, which are of medium size ; the protoplasm 
is pale grey. The nuclei are small and very irregular, measuring 
9*75 x 10*95 g. The chromatin is not abundant. The small 
rounded karyosomes stain blue, and are often very scanty. The 
lanthanin granules are scanty and pale blue-grey. Extrusion of 
nucleoli is still progressing. 
Three hours after food. — (Fig. 7, coloured plate, photo 6.) — 
Lumen very wide, cells often reduced to narrow strips, containing 
few zymogen granules that are mostly confined to their free ex- 
