1898 — 99 .] Prof. Carlier on Changes in Newt’s Stomach. 
683 
nucleoli are mostly large, and are being freely extruded. There is 
no mitosis present. 
Seventeen hours after food . — The lumen is now small, and the 
cells are filled with large zymogen granules, those near the free 
extremities of the cells being somewhat smaller than the others. 
The cytoplasm is pale grey. The nuclei are large and deeply 
stained ; they measure 11 '82 x 14*88 /a, and contain chromatin of 
a deep blue colour. Lanthanin granules are abundant and stain 
deep blue, with a decided lilac tint. Nucleoli are often large, and 
some are being extruded. 
By the nineteenth or twentieth hour the cells have again come to 
rest, and some mitotic figures make their appearance in them. 
The cells lining the surface of the stomach, and those of the 
pyloric glands and necks of the oxyntic glands, have also been 
carefully studied. Although their secretion is of a different nature 
from that of the oxyntic cells, they exhibit during activity and 
repair precisely the same nuclear changes as the oxyntic cells. 
Therefore, without wearying you with further details, I may pass 
at once to the conclusions I have drawn from this investigation. 
Resume anp Conclusions. 
As soon as the food is swallowed secretion commences in the 
oxyntic glands of the stomach, and sweeps in a slow wave along 
the whole organ, commencing at the oesophageal opening and 
passing off at the pyloric end at such a rate that the cells near the 
pyloric extremity reach their maximum activity some one and a 
half to two hours after those near the oesophagus. 
For any one cell, the wave reaches its maximum between the 
third and fourth hour or hour and a half, and is followed by a 
period of rest and recuperation, which lasts for another four or five 
hours; after which, if food is still present in the stomach, the 
cells again enter upon a second secretory period that follows the 
same course as the first. 
According to Langley, and Langley and Sewall (13), the cells 
continue to secrete actively during the period of repair, statements 
which they base mainly on their experimental researches on the 
quantity of digestive substances present in the stomach, and on 
