DR. S. H. LONG ON TIIE MOSQUITO-MALARIA THEORY. 193 
were conducted in Rome, the hot-bed of Malaria ; and being in 
a foreign country would not impress the sceptical in this country in 
the same way as if such a demonstration had been undertaken in 
our midst. “ It occurred to me, therefore,” Dr. Manson goes on to 
say, “ that if I repeated Grassi and Rignami’s experiments in 
a more dramatic and crucial manner, that if I fed laboratory-reared 
Mosquitoes on a malarial patient in a distant country and subse- 
quently carried the Mosquitoes to the centre of London, and there 
set them to bite some healthy individual free from any suspicion 
of being malarial, and if this individual within a short period of 
being bitten developed malarial fever, and showed in his blood the 
characteristic parasite, the conclusion that Malaria is conveyed by 
the Mosquito would be evident to every understanding, and could 
not possibly be evaded.” An experiment of this nature was made 
last year, and the subject of it was Dr. Manson’s son, a medical 
student of Guy’s Hospital. Mosquitoes were fed in Rome upon 
a subject of Malaria of the benign tertian type ; the purity of the 
infection having been previously determined by many repeated 
examinations of the patient’s blood. These Mosquitoes were then 
despatched to London in a specially constructed cage covered with 
Mosquito netting on a wire frame. In forty-eight hours they 
arrived in London, some having died on the journey, though several 
still survived. Mr. Manson allowed the Mosquitoes to infect him 
by placing his hand in the cage and letting the Mosquitoes bite it. 
As, however, the first consignment of Mosquitoes were languid after 
their journey they did not bite well, and so a second and a third 
lot were sent; twenty-five of these latter bit Mr. Manson on one 
day and ten on the next. In due course Mr. Manson developed 
typical tertian Ague, and the parasites known to cause this type of 
the disease were found in his blood by several skilled and inde- 
pendent medical men. After a period of about four days, quinine 
was administered to him, and the shivering fits ceased, and within 
a few hours the parasites had disappeared from his blood. 
The other experimental proof that I will quote to you is the 
following: — During this last summer (1900) two medical men, 
Drs. Sambon and Lowe from the London School of Tropical Medi- 
cine, being convinced of the truth of the Mosquito-Malaria Theory, 
volunteered to go out to Italy and live on the Roman Campagna 
for four months (June — October) during the height of the malarial 
