1888 - 89 .] Paton and Stockman on Metabolism of Man. 125 
inflamed. His pulse was 84 at 12 noon, the only occasion on which 
it rose so high ; hut his temperature was only 96 0, 8-97 0, 8 F. Since 
a few days after the completion of his fast he had a well-marked 
attack of gout, it is fair to conclude that this also was a slight 
attack of the same disease. 
One very important point, upon which we hoped to gain valuable 
information, was the influence of exercise on the metabolism during 
starvation. Unfortunately, it was not possible to get results at all 
satisfactory. In the first place, the amount of exercise taken was 
exceedingly small ; in the second place, it was not easy to estimate 
the precise amount of exercise taken daily. Inasmuch as during the 
hours spent indoors practically no exercise was indulged in, we came 
to the conclusion that the most satisfactory results might be arrived 
at by taking, as a measure of the muscular exercise, the duration of 
his daily walks. 
It is to be regretted that the conditions of the fast and the pres- 
sure of other work rendered it impossible for us to undertake anything 
like the complete series of observations carried out in Cetti’s case. 
The following observations only could be accomplished : — 
The weight was daily taken before Jacques had dressed. The 
amount of fluid consumed was carefully measured. The urine passed 
was all collected and measured. Its reaction was taken, and the 
amount of urea estimated by the hypobromite method — Dupre’s 
apparatus, previously tested on standard solutions of urea, being 
used. A record of the pulse, temperature, and general condition 
was also kept. 
From the urea the daily waste of flesh was calculated. By this 
term is, of course, meant not merely the muscle substance, but all 
the various tissues of the body containing nitrogen in the proportion 
in which this occurs in muscle. 
The difference between this and the total loss of weight gave the 
loss of non-nitrogenous substances. These non-nitrogenous wasting 
substances are the fats and carbohydrates ; but inasmuch as the 
latter occur only in small quantities, and are rapidly used up, they 
may be neglected, and we may consider these non-nitrogenous matters 
as practically entirely composed of fat. 
Of course, the possibility of variations in the percentage amount of 
water in the body had to be considered, and in all probability this 
