368 DR. EVANS ON THE POISONED SPINES OF THE WEEVER FISH. 
Seven tubes were filled with 1 C. C. of 5 % emulsion. 
With 1 drop Weever poison slight haemolysis. 
With 2 ,, ,, ,, well marked, 
With 2 ,, ,, ,, + .05 C. C. normal serum, 
strong haemolysis. 
With 2 ,, ,, ,, + serum heated for half an 
hour at 62° C. slight. 
The controls were all negative. 
Ox blood gave similar results. 
With 2 drops Weever poison well marked haemolysis. 
With 2 ,, ,, ,, + .5 C. C. 1-10 normal serum, 
well marked. 
With 2 „ ,, ,, — .5 C. C. 1-10 heated serum, 
strong haemolysis. 
The results of these experiments amount to the establish- 
ment of the existence of a haemolytic property in Weever 
venom capable of dissolving washed corpuscles of all bloods 
so far experimented on without the addition of sera. That 
the addition of the serum of the same animal does not inhibit 
but rather increases the activity of the venom. That in 
most cases heating the serum for an hour to 62° C. diminishes 
its activating power. That minimal doses of the venom can 
be activated by the sera of other animals in the case of man, 
or the corpuscles are rendered more susceptible to the poison. 
That probably the poison is an amboceptor, which unites with 
the endocomplements of the blood cells. 
The neurotoxic effects of the poison have not been fully 
worked out at present, as I have been unable to spare the 
time away from practice, but I am continuing my investi- 
gations in this direction and also studying the effect of the 
venom on bacteriolysis. 
Treatment. Recent cases have been treated successfully by 
the following method. The part pricked should be separated 
from the general circulation by a ligature, and if the lips are 
not sore the wound should be sucked. The wound should 
then be freely incised and a fresh solution of permanganate of 
potash, or hypochlorite of lime, or chloride of gold 1 % rubbed 
into the part. 
