426 Proceedings of the Royal Society of Edinburgh. [Sess. 
6. The result of these observations helps to explain the different effects 
of chloroform on hepatic metabolism. When given by the respiratory 
passages it is rapidly eliminated, produces no marked histological 
changes, and the metabolic disturbances are slight ; but when given by the 
mouth and hypodermically it is more slowly eliminated, has more time to 
produce its toxic action, and the metabolic disturbances are pronounced. 
In a future paper the action of chloroform upon the blood corpuscles 
will be dealt with. 
A grant was received from the Carnegie Trust to defray the expenses 
of this research. 
REFERENCES. 
(1) D. Noel Paton, Proc. Roy. Soc. Edin., vol. xxviii., 1907-8, p. 472. 
(2) D. Noel Paton and Miss Lindsay, Proc. Roy. Soc. Edin., vol. xxviii., 
1907-8, p. 497. 
(3) Stiles and McDonald, Scottish Medical and Surgical Journal , Aug. 1904, 
p. 97. 
(4) Fraenkel, Virchow's Archiv , Bd. cxxvii. S. 381, and Bd. cxxix. S. 254. 
(5) Marthen, Berlin ldin. Woch ., 1896, No. 10. 
(6) Cohn, Deutsche Zeitsch. f. Chir ., 1902, Bd. ixiv. 
(7) Junkers, Tiber fettige Entartung infolge von Chlorof. Inhalat., Bonn, 1883. 
(8) Strassmann, Virchow's Archiv , 1889. 
(9) Nothnagel, Berlin Min. Woch., 1866. 
(10) Ostertag, Virchow's Archiv , 1889, Bd. cxviii. S. 250. 
(11) D. Noel Paton, Phil. Trans. Roy. Soc., 1894, vol. clxxxv. p. 248. 
(12) Castaigne and Rathery, Arch, de med. exper. et d'anat. path., Sept. 1903. 
(13) Doyon, Compt. rend. Soc. de biol., vol. lviii. pp. 30, 108, 853. 
( Issued separately July 9, 1909.) 
