543 
1908-9.] The Pathogenesis of Micrococcus melitensis. 
and is followed by a period extending over from three to six days, during 
which the animal is distinctly ill and refuses its food ; remains huddled up 
Note. — In all the following charts the temperature is shown by the continuous line : the thick 
interrupted line © - - records the titre of the serum, and the thinner line - - - - the weight of 
the experimental animal. 
CHART 1. 
Intracerebral 
Inoculation. 
Animal 
• • . 
. . . guinea-pig 
Weight 
. 
. . . 480 grams 
Sex 
• . • 
male 
Dose 
• 
. . . 1 - 0 loop 
Duration of infection . 
27 hours 
in one corner of its cage ; loses weight rapidly, and becomes extremely weak. 
Convulsions of a mild type can usually be provoked at the beginning of 
this stage by handling the animal or by turning it on to its back. 
