555 
1908-9.] The Pathogenesis of Micrococcus melitensis. 
The dog is susceptible to infection by intracerebral, intravenous, intra- 
peritoneal, and subcutaneous inoculation with living cultivations of 
M. melitensis — probably also by feeding with infective material, although 
I have not personally conducted any experiments in this direction, nor do 
I know of any recorded observations on this method of infection in 
the dog. 
CHART 8. 
Animal .... smooth-haired terrier 
Sex ..... male 
Dose . . . . . 0 ‘5 agar culture 
Killed 30th day of infection. 
Clinical symptoms produced as a direct result of the intravenous, intra- 
peritoneal, or subcutaneous inoculation of dogs with living cultures of 
M. melitensis are conspicuous by their absence. The experimental animal 
may or may not be listless and “ off food ” for a day or two, and the 
temperature may rise a degree or so, but usually no suggestion of illness 
can be detected, and the animal appears to be totally unaffected ; while the 
infection apparently has no deleterious influence in the direction of shorten- 
