569 
1908-9.] The Pathogenesis of Micrococcus melitensis. 
In some cases of extreme chronicity, where the infection has pursued a 
very protracted course, and the temperature, though very irregular, has 
rarely risen above 40° C., the specific organism can often be recovered only 
from the lymphatic glands and urine (see chart 16). 
Infection by Feeding . — In a series of experimental feedings with 
infective goats’ milk in the summer of 1905, 93 per cent, of the monkeys 
were successfully infected, which sufficiently demonstrates their suscepti- 
bility to this form of infection. On the clinical aspect of the infection 
produced by feeding experiments it is unnecessary to dwell at length, hut 
a few points of interest may be briefly mentioned : — 
Temperature . — Speaking generally, the infection appears to be mild, 
as judged by the course of the experimental animals’ temperature and 
supported by their general appearance and behaviour during the six or 
seven weeks some were under observation, but opinions based upon clinical 
symptoms were rudely contradicted by the result of the post-mortem 
examinations. 
Again, speaking generally, the temperature chart of the Rhesus infected 
with M. melitensis, except in the case of very severe infections such as follow 
intracranial and intravenous injections of the micrococcus, shows but one 
period of pyrexia, followed by an intermittent temperature of slight range 
and short duration. A second period of pyrexia, or “ wave ” as it is 
colloquially termed, is quite the exception. The remittent type of pyrexia 
does, however, occur in the monkey ; also this animal sometimes exhibits a 
type of temperature absolutely comparable to the one obtaining in man 
when the subject of what Shaw has designated the “ ambulatory ” type of 
M. melitensis septicaemia. 
All these three types are met with in the course of experimental feed- 
ings, as will be seen in the three accompanying charts (17, 18, and 19), 
which I have selected from the many in my possession. In these three 
animals the severity of the infection must have been of nearly equal 
intensity in these cases, judging by the results of the bacterioscopic 
examination, which showed that the blood and all the organs of each of 
these animals were literally teeming with the M. melitensis. 
Agglutination Reaction . — The repeated examinations that were made of 
blood from each of the infected monkeys showed that for a day or two, or 
even several days, before a definite reaction was obtainable a 1 : 10 dilution 
of the serum produced microscopically what is regarded as an “ incomplete ” 
reaction — that is, the micrococci ceased to exhibit active vibratory move- 
ment and adhered together in small bunches ; but large clumps and masses 
were not formed, and the general field was made up of discrete cocci. Then 
