571 
1908-9.] The Pathogenesis of Micrococcus melitensis. 
animals early in the course of the disease, are responsible for the fact that 
but few examples of the development of a very high agglutinative power 
in the serum were noted. 
Man . — Man is susceptible to infection by subcutaneous inoculation, to 
infection through apparently intact mucous membranes, and the administra- 
tion of infective food. Laboratory inoculations in which man has served 
as the experimental animal, though not intentional, are sufficiently numerous 
to enable us to say that the type of infection which results compares ab- 
solutely with that naturally acquired within endemic areas, and also enable 
us to fix within fairly narrow limits the period of incubation for sub- 
cutaneous infections. Thus of eight cases of laboratory infection where 
