CONDITION OP EPIDERMAL FIBRILS IN EPITHELIOMA. 285 
cells lyiug above the cutis vera, the fibrils have a direction 
parallel to the long axis of the cell, and pass at their lower 
end into the cutis vera. Hence Kromayer is of the opinion 
that it is owing to the greater cohesion given by the extension 
of the fibrils into the cutis, that in blistering the blister is 
formed between the basal columnar layer and the layer of 
cells above, and not between the basal layer and the cutis 
vera. 
Schridde’s (1905) work is of a more comprehensive 
character. His observations were made on healthy skin, and 
also on the skin from the margins of lupus areas and of a 
tumour on the vola manus, caused by X rays. Like the 
preceding* authors, he found that the fibrils are more readily 
observable in pathological material, but that, nevertheless, 
the character of the fibrils is the same in both healthy and 
unhealthy tissue. His observations led him to conclude that 
(1) the fibrils have a definite arrangement and are disposed 
in at least three series, taking a circular or elliptical path, 
and in such a way that the nuclei of the cells traversed lie 
outside the fibrils. This is more easily expressed in the 
diagram, which, to avoid a long description, is herewith 
reproduced from his paper. (2) The keratohyalin of the 
stratum granulosum is not derived entirely from broken-down 
